Minor Emily A, Newman Mackenzie S, Kupec Justin T
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA.
Department of Digestive Diseases, West Virginia University School of Medicine, Morgantown, WV, USA.
Case Reports Hepatol. 2018 Sep 10;2018:1619546. doi: 10.1155/2018/1619546. eCollection 2018.
Historically used as an anesthetic, chloroform is a halogenated hydrocarbon that is associated with central nervous system depression, arrhythmias, and hepatotoxicity. It is no longer used clinically, but accidental and intentional poisonings still occur. We report a case of chronic chloroform abuse leading to severe hepatotoxicity in a 26-year-old male graduate student. The patient presented to the emergency department with a three-day history of abdominal pain, dehydration, and scleral icterus. He drank several beers the night before the onset of symptoms, but denied taking acetaminophen, ibuprofen, or other drugs. An extensive work-up revealed an aspartate aminotransferase (AST) of 13,527 U/L and alanine aminotransferase (ALT) of 8,745 U/L, but the cause of his liver injury could not be determined. It was not until many months later that the patient admitted to inhaling chloroform in the weeks leading up to his illness.
氯仿在历史上曾用作麻醉剂，是一种卤代烃，与中枢神经系统抑制、心律失常及肝毒性有关。它目前已不再用于临床，但意外中毒和故意中毒仍有发生。我们报告一例26岁男性研究生因长期滥用氯仿导致严重肝毒性的病例。该患者因腹痛、脱水和巩膜黄染3天就诊于急诊科。他在症状出现前一晚喝了几杯啤酒，但否认服用对乙酰氨基酚、布洛芬或其他药物。全面检查显示天冬氨酸转氨酶（AST）为13527 U/L，丙氨酸转氨酶（ALT）为8745 U/L，但肝损伤原因无法确定。直到数月后，患者才承认在发病前几周吸入了氯仿。
