Hood S, Nicholls M G, Gilchrist N L
N Z Med J. 1987 Jan 28;100(816):6-7.
Since there are isolated case reports linking cough with angiotensin converting-enzyme (ACE) inhibitor treatment, we reviewed the case notes of patients attending a hypertension outpatient clinic. Of 126 patients, 37 were on medications other than ACE inhibitors, and none complained of cough. In contrast, 12 of 89 patients receiving an ACE inhibitor had noted cough. The symptoms remained when one ACE inhibitor was substituted for another, but disappeared when the drug was withdrawn. Cough was sufficiently irritating to require cessation of treatment in two patients. We conclude that cough is not uncommon during treatment with ACE inhibitors.
由于有个别病例报告将咳嗽与血管紧张素转换酶（ACE）抑制剂治疗联系起来，我们查阅了高血压门诊患者的病历。126名患者中，37名服用的不是ACE抑制剂，无人主诉咳嗽。相比之下，89名接受ACE抑制剂治疗的患者中有12名出现咳嗽。换用另一种ACE抑制剂时症状依然存在，但停药后症状消失。咳嗽严重到足以使两名患者停药。我们得出结论，ACE抑制剂治疗期间咳嗽并不罕见。
