Reisin L, Schneeweiss A
Heart Institute, Barzilai Hospital, Ashkelon, Israel.
J Hum Hypertens. 1992 Aug;6(4):333-5.
The files of 172 consecutive hypertensive patients who received captopril or enalapril have been reviewed and the patients questioned on the development of chronic dry cough, persisting for at least two months. Forty patients had cough that was attributed to the drugs. Thirteen of them discontinued the drugs because of this adverse effect. In 15 of the 27 patients (55%) who continued receiving ACE inhibitors (7 males, 8 females, aged 65.4 +/- 9.9 years) the cough had spontaneously disappeared after 3.9 +/- 1.9 months of continued unaltered administration of these drugs and without any treatment aimed against this symptom. All patients were followed for at least four months after disappearance of cough, without recurrences. This finding may discourage withdrawal of ACE inhibitors from many patients who develop cough. Continuation of ACE inhibitors for at least several months, despite cough, (if the cough is not too severe) is probably justifiable.
回顾了172例连续接受卡托普利或依那普利治疗的高血压患者的病历，并询问了患者慢性干咳（持续至少两个月）的发生情况。40例患者的咳嗽归因于药物。其中13例因这种不良反应而停药。在继续接受ACE抑制剂治疗的27例患者中，有15例（55%）（7例男性，8例女性，年龄65.4±9.9岁）在继续不变地服用这些药物3.9±1.9个月后，咳嗽自行消失，且未针对该症状进行任何治疗。所有患者在咳嗽消失后至少随访了四个月，无复发。这一发现可能会使许多出现咳嗽的患者不再停用ACE抑制剂。尽管咳嗽，（如果咳嗽不太严重）继续服用ACE抑制剂至少几个月可能是合理的。
