University of Agronomic Science and Veterinary Medicine, Faculty of Biotechnology, 59 Marasti Blvd, 1 District, 011464, Bucharest, Romania.
Curr Pharm Des. 2018;24(35):4144-4149. doi: 10.2174/1381612824666181001154242.
Two pathologies commonly associated with gut microbiota dysbiosis are type 2 diabetes and cardiovascular diseases. Since diet and medication are two important causes of microbiome fingerprint modifications, new complementary and alternative methods can include wild edible mushrooms, which serve as functional products, given their properties in modulating the microbial pattern at the colon level. A disturbance in microbial balance translates into the occurrence of degenerative dysfunctions that are also associated with other pathologies, such as obesity, colon cancer. The metagenomic study has enabled the identification of some competitive microbiological and biochemical biomarkers which allow the development of innovative strategies in controling microbial disbalance from human gut. Thus, the aim of this review was to present the significant findings related to human microbiome modulation via the prebiotic effects of wild edible mushrooms as a complementary strategy to modern treatment. Certain mushroom species have been approached and their effects on the microbiota fingerprint of two major target groups are highlighted.
两种常见与肠道微生物失调相关的病症是 2 型糖尿病和心血管疾病。由于饮食和药物是微生物组指纹改变的两个重要原因，新的补充和替代方法可以包括野生食用菌，由于其在调节结肠水平微生物模式方面的特性，它们可用作功能性产品。微生物平衡的干扰转化为退行性功能障碍的发生，这些退行性功能障碍也与其他病症相关，如肥胖、结肠癌。宏基因组学研究已经能够确定一些竞争性微生物学和生物化学生物标志物，这些标志物允许开发创新性策略来控制人类肠道中的微生物失衡。因此，本综述的目的是介绍通过野生食用菌的益生元作用调节人类微生物组的重要发现，作为现代治疗的补充策略。已经研究了某些蘑菇物种，并强调了它们对两个主要目标群体的微生物组指纹的影响。
