Vamanu Emanuel, Gatea Florentina
Faculty of Biotechnology, University of Agronomic Science and Veterinary Medicine, 59 Marasti blvd, 1 district, 011464 Bucharest Romania.
Centre of Bioanalysis, National Institute for Biological Sciences, 296 Spl. Independentei, 060031 Bucharest, Romania.
Biomedicines. 2020 Feb 20;8(2):39. doi: 10.3390/biomedicines8020039.
Numerous studies have demonstrated the role of the microbiota in supporting the physiological functions, owing to its metabolomic component. The presence of biocomponents generally leads to the correction of the microbial pattern correlated with the reduction of oxidative pressure. This study aims to present the main processes that correlate the bioavailability and bioactivity of some functional components through the action of the human microbiota. The use of probiotics and prebiotics is an innovative manner involving alternatives that increase the bioavailability of certain natural or metabolic components has been proposed. Probiotic strains ( or ) may represent an intermediary for increasing the antioxidant bioactivity, and they may be administered in the form of a biomass enriched with functional compounds, such as phenolic acids. The limiting effect of gastrointestinal transit is, in several cases, the key to the biopharmaceutical value of new products (or supplements). The identification of newer ways of formulating supplements also involves the compatibility of different types of products, the testing of bioaccessibility, and the elimination of biotransformations.
大量研究表明，由于其代谢组学成分，微生物群在支持生理功能方面发挥着作用。生物成分的存在通常会导致与氧化压力降低相关的微生物模式得到纠正。本研究旨在介绍通过人类微生物群的作用使某些功能成分的生物利用度和生物活性相关联的主要过程。益生菌和益生元的使用是一种创新方式，有人提出了增加某些天然或代谢成分生物利用度的替代方法。益生菌菌株（或）可能是提高抗氧化生物活性的媒介，它们可以以富含功能性化合物（如酚酸）的生物质形式给药。在几种情况下，胃肠道转运的限制作用是新产品（或补充剂）生物制药价值的关键。确定补充剂的新配方方式还涉及不同类型产品的兼容性、生物可及性测试以及生物转化的消除。
