可乐定对血浆3-甲氧基-4-羟基苯乙二醇的影响：反对去甲肾上腺素能功能的紧张性α2-肾上腺素能受体控制的证据。

The effect of clonidine on plasma MHPG: evidence against tonic alpha 2-adrenoceptor control of noradrenergic function.

作者信息

Nutt D J, Molyneux S G

出版信息

Psychopharmacology (Berl). 1986;90(4):509-12. doi: 10.1007/BF00174070.

Abstract

The effect of the alpha 2-adrenoceptor agonist clonidine on plasma free MHPG levels was assessed in 12 normal volunteers. A significant fall in MHPG was produced by 1.5 microgram X kg-1 clonidine IV whereas saline had no effect. The peak fall in MHPG correlated strongly with the area under the curve (AUC). In addition, a strong correlation was seen between basal MHPG and the extent of the clonidine-induced fall. This suggests that plasma MHPG levels are not simply a reflection of central alpha 2-adrenoceptor function and argues against tonic alpha 2-adrenoceptor-mediated inhibitory control of noradrenergic output.

摘要

在12名正常志愿者中评估了α2 -肾上腺素能受体激动剂可乐定对血浆游离3 -甲氧基- 4 -羟基苯乙二醇（MHPG）水平的影响。静脉注射1.5微克/千克的可乐定可使MHPG显著下降，而注射生理盐水则无此作用。MHPG的最大降幅与曲线下面积（AUC）密切相关。此外，基础MHPG水平与可乐定引起的下降程度之间也存在很强的相关性。这表明血浆MHPG水平并非仅仅是中枢α2 -肾上腺素能受体功能的反映，也反驳了α2 -肾上腺素能受体介导的对去甲肾上腺素能输出的紧张性抑制控制的观点。