Jiang Meng-Yuan, Luo Ming, Tian Kai, Li Yan-Hong, Sun Jing-Xian, Lu Ya, Pu Xiao-Yun, Huang Xiang-Zhong
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan, P. R. China.
Planta Med. 2019 Jan;85(2):112-117. doi: 10.1055/a-0746-8622. Epub 2018 Oct 2.
Four new coumestans dolichosins A - D (1: -4: ) were isolated from the roots of , together with four known compounds: isosojagol (5: ), phaseol (6: ), psoralidin (7: ), and 4″,5″-dehydroisopsoralidin (8: ). Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analyses, and the comparison with literature data of related compounds. The anti-inflammatory activity of these compounds (1: -8: ) was evaluated through the inhibition of nitric oxide production in lipopolysaccharide-activated murine macrophage RAW 264.7 cells, in which compounds 1: and 6: displayed moderate inhibitory activity and no cytotoxic effects. In a -glucosidase inhibitory assay, compounds 1: and 5: -8: exhibited appreciable inhibition on -glucosidase. Especially compounds 1, 7: , and 8: showed IC values lower than 20.0 µM.
从[植物名称]的根部分离出了四种新的豆甾烷型香豆素——多利可辛A-D（1：-4：），以及四种已知化合物：异大豆黄素（5：）、菜豆素（6：）、补骨脂定（7：）和4″,5″-脱氢异补骨脂定（8：）。通过光谱数据解析、质谱分析以及与相关化合物文献数据的比较，阐明了它们的结构。通过抑制脂多糖激活的小鼠巨噬细胞RAW 264.7细胞中一氧化氮的产生，评估了这些化合物（1：-8：）的抗炎活性，其中化合物1：和6：表现出中等抑制活性且无细胞毒性作用。在α-葡萄糖苷酶抑制试验中，化合物1：和5：-8：对α-葡萄糖苷酶表现出明显的抑制作用。特别是化合物1、7：和8：的IC值低于20.0 μM。
