Xu Bing, Fang Zhen, He Shenghu, Wang Junhong, Yang Xiangjun
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou.
Department of Cardiology, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou.
Medicine (Baltimore). 2018 Sep;97(39):e12641. doi: 10.1097/MD.0000000000012641.
Several studies have shown that ANRIL polymorphism may be associated with the risk of coronary artery disease (CAD). However, these studies do not provide a clear consensus in Asian population. Thus, this meta-analysis was aimed to evaluate the relationship between the common variant rs4977574 in ANRIL and CAD risk in Asian population.
We conducted a systematic literature search of PubMed, Embase and the Cochrane Library and 2 Chinese databases. A total of 12,005 subjects from 6 independent studies were included. The pooled odds ratio (OR) and their corresponding 95% confidence intervals (CIs) were used to assess the association between rs4977574 and CAD using random effects model.
A significant association was observed between rs4977574 and CAD risk under the allelic (OR: 1.18, 95% CI: 1.04-1.34, P = .010), recessive (OR: 1.27, 95% CI: 1.01-1.60, P = .04), dominant (OR: 1.28, 95% CI: 1.13-1.44, P = .002), homozygous (OR: 1.46, 95% CI: 1.15-1.86, P = .002), and heterozygous model (OR: 1.17, 95% CI: 1.07-1.28, P = .0004), especially in the Chinese subgroup and the myocardial infarction (MI) subgroup (P < .05).
The ANRIL polymorphism rs4977574 is associated with CAD risk in Asian population. The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
多项研究表明，ANRIL基因多态性可能与冠状动脉疾病（CAD）风险相关。然而，这些研究在亚洲人群中并未达成明确共识。因此，本荟萃分析旨在评估ANRIL基因常见变异rs4977574与亚洲人群CAD风险之间的关系。
我们对PubMed、Embase和Cochrane图书馆以及两个中文数据库进行了系统的文献检索。共纳入了来自6项独立研究的12005名受试者。采用随机效应模型，通过合并比值比（OR）及其相应的95%置信区间（CI）来评估rs4977574与CAD之间的关联。
在等位基因模型（OR：1.18，95%CI：1.04 - 1.34，P = 0.010）、隐性模型（OR：1.27，95%CI：1.01 - 1.60，P = 0.04）、显性模型（OR：1.28，95%CI：1.13 - 1.44，P = 0.002）、纯合子模型（OR：1.46，95%CI：1.15 - 1.86，P = 0.002）和杂合子模型（OR：1.17，95%CI：1.07 - 1.28，P = 0.0004）下，均观察到rs4977574与CAD风险之间存在显著关联，尤其是在中国亚组和心肌梗死（MI）亚组中（P < 0.05）。
ANRIL基因多态性rs4977574与亚洲人群的CAD风险相关。携带G等位基因的rs4977574可能会增加CAD风险，尤其是MI风险。
