Department of Cardiology, Peking University People's Hospital, Beijing, China.
Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital, Beijing, China.
Biosci Rep. 2019 Nov 29;39(11). doi: 10.1042/BSR20192721.
Previous studies have explored associations between interleukin-18 (IL-18) promoter polymorphisms and coronary artery disease (CAD). However, the results were controversial. We conducted a meta-analysis to clarify the association between the two polymorphisms and CAD risk.
We searched English and Chinese databases and calculated the odds ratio (OR) and 95% confidence interval (CI) to estimate whether there are genetic associations between IL-18 promoter polymorphisms and the risk of CAD. All relevant studies were screened and meta-analyzed using STATA 15.0.
A total of 15 studies, including 12 studies for -137 G/C and 9 studies for -607 C/A, were identified for the meta-analysis. For -137 G/C, the results showed a significantly reduced risk of CAD in the dominant model (OR = 0.85) and heterozygous model (OR = 0.88) in the overall analysis. However, in subgroup analysis, decreased CAD risks were only observed in Asian populations for heterozygous genetic models. For -607 C/A, the overall OR revealed a reduced risk of CAD in all five genetic models (allelic, OR = 0.78; recessive, OR = 0.75; dominant, OR = 0.68; homozygous, OR = 0.61; heterozygous, OR = 0.72). In subgroup analysis, reduced CAD risk was also found in five genetic models of the Asian population. We also found that the IL-18 polymorphisms were correlated with myocardial infarction (MI) and multivessel (MV) disease.
Our results suggested that the -137 polymorphism and -607 polymorphism in the IL-18 promoter were negatively associated with CAD, especially in the Asian population. In addition, some genetic models were correlated with the severity of CAD.
先前的研究探讨了白细胞介素-18（IL-18）启动子多态性与冠状动脉疾病（CAD）之间的关联。然而，结果存在争议。我们进行了一项荟萃分析，以阐明这两种多态性与 CAD 风险之间的关联。
我们搜索了英文和中文数据库，并计算了比值比（OR）和 95%置信区间（CI），以评估 IL-18 启动子多态性与 CAD 风险之间是否存在遗传关联。使用 STATA 15.0 筛选并荟萃分析所有相关研究。
共纳入 15 项研究，其中 12 项研究针对 -137 G/C，9 项研究针对 -607 C/A 进行荟萃分析。对于 -137 G/C，总体分析中，显性模型（OR = 0.85）和杂合模型（OR = 0.88）均显示 CAD 风险显著降低。然而，在亚组分析中，仅在亚洲人群的杂合遗传模型中观察到 CAD 风险降低。对于 -607 C/A，所有五种遗传模型的总体 OR 均显示 CAD 风险降低（等位基因，OR = 0.78；隐性，OR = 0.75；显性，OR = 0.68；纯合，OR = 0.61；杂合，OR = 0.72）。在亚组分析中，亚洲人群的五种遗传模型也发现 CAD 风险降低。我们还发现，IL-18 多态性与心肌梗死（MI）和多血管（MV）疾病相关。
我们的结果表明，IL-18 启动子中的 -137 多态性和 -607 多态性与 CAD 呈负相关，尤其是在亚洲人群中。此外，某些遗传模型与 CAD 的严重程度相关。
