Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France.
UMR INSERM, 1027 University of Toulouse III, Toulouse, France.
Am J Alzheimers Dis Other Demen. 2019 Mar;34(2):89-94. doi: 10.1177/1533317518803773. Epub 2018 Oct 3.
Examine the effects of a 6-month exercise intervention on neuropsychiatric symptoms, pain, and medication consumption in older people with dementia (PWD) living in nursing homes (NH).
Ninety-one older PWD living in NH performed a 6-month structured exercise intervention (n = 44) or a social activity intervention (n = 47). Neuropsychiatric symptoms were measured by the neuropsychiatric inventory (NPI), pain was assessed using the Algoplus scale, and dementia-related drug prescriptions were obtained for all participants.
Between-group analysis found a nonsignificant difference that could be of clinical relevance: a 4-point difference in the NPI and 1.3-point difference in the reduction of the number of medications favoring exercisers. No significant differences were found for pain, and a trend was found for an increase in medication consumption in the social group.
Exercise effects did not differ from social intervention effects on neuropsychiatric symptoms, pain, and medication consumption in older PWD living in NH.
探讨为期 6 个月的锻炼干预对居住在养老院（NH）的老年痴呆症（PWD）患者的神经精神症状、疼痛和药物使用的影响。
91 名居住在 NH 的老年 PWD 参加了为期 6 个月的结构化锻炼干预（n=44）或社交活动干预（n=47）。使用神经精神疾病问卷（NPI）评估神经精神症状，使用 Algoplus 量表评估疼痛，并为所有参与者获取与痴呆相关的药物处方。
组间分析发现了一个可能具有临床意义的无显著性差异：NPI 得分差异 4 分，药物使用数量减少 1.3 分，锻炼组更有利。在疼痛方面没有发现显著差异，社交组的药物使用呈增加趋势。
在 NH 居住的老年 PWD 中，运动干预与社交干预对神经精神症状、疼痛和药物使用的影响没有差异。
