School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
Int J Mol Med. 2018 Dec;42(6):2979-2990. doi: 10.3892/ijmm.2018.3911. Epub 2018 Oct 2.
Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, expression, and assembly of the NLRP3 inflammasome, and highlights its potential as a novel therapeutic target for ischemic stroke.
缺血性脑卒中是全球范围内主要的死亡和致残原因之一。NLR 家族富含pyrin 结构域蛋白 3（NLRP3）炎性小体被确定为一种在缺血性脑卒中进展过程中检测细胞损伤和调节炎症反应的传感器。在不同阶段抑制或阻断 NLRP3 炎性小体，包括表达、组装和分泌，可能对改善缺血性脑卒中期间的神经功能缺损具有重要意义。本综述全面总结了 NLRP3 炎性小体的分子结构、表达和组装的文献中的最新认识，并强调了其作为缺血性脑卒中新型治疗靶点的潜力。
