School of Mechanical Engineering, Shandong University, Jinan, 250061, China.
Key Laboratory of High Efficiency and Clean Mechanical Manufacture (Shandong University), Ministry of Education, Jinan, 250061, China.
Med Biol Eng Comput. 2019 Mar;57(3):615-622. doi: 10.1007/s11517-018-1891-3. Epub 2018 Oct 2.
Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolution, the heterogeneous and anisotropic corona radiata cannot be taken as a homogeneous whole body. In this work, indentation experiments were conducted on the anterior, superior, and posterior regions of the corona radiata in the sagittal plane. To determine the parameters available for computational modeling purposes, a linear viscoelastic model using the Boltzmann hereditary integral was fitted to the force-time data of the three regions. In the indentation tests, the superior region appeared to be the stiffest, while no significant differences were observed between the anterior and posterior regions until the viscoelastic tissue reached equilibrium. During the period of relaxation, statistical comparisons among the different regions indicated significant differences between the superior and anterior regions, and between the superior and posterior regions. This work complements existing investigations into the anatomic heterogeneity of the brain, and contributes toward improving the spatial resolution of future computational models. Graphical abstract Relaxation functions of different regions based on the Prony series parameters and the multiregional Kolmogorov-Smirnov comparisons (*p < 0.017). The anisotropy and interregional differences of the corona radiata observed in this study are supplementary to the previous explorations of the mechanical properties of different brain anatomic structures.
详细的有限元（FE）模型被用作研究创伤性脑损伤的有前途的工具，尽管它们的准确性强烈依赖于大脑中不同解剖结构的力学行为的特征化。在某些情况下，当 FE 模型需要更精细的空间分辨率时，异质各向异性的冠状辐射区不能被视为均质的整体。在这项工作中，在冠状辐射区的矢状面的前、上和后区域进行了压痕实验。为了确定可用于计算建模目的的参数，使用 Boltzmann 遗传积分的线性粘弹性模型拟合了三个区域的力-时间数据。在压痕试验中，上区域似乎最硬，而在前部和后部区域之间没有观察到明显差异，直到粘弹性组织达到平衡。在松弛期间，不同区域之间的统计比较表明，上区域和前区域之间以及上区域和后区域之间存在显著差异。这项工作补充了对大脑解剖异质性的现有研究，并有助于提高未来计算模型的空间分辨率。基于 Prony 级数参数和多区域 Kolmogorov-Smirnov 比较的不同区域的松弛函数（*p<0.017）。本研究中观察到的冠状辐射区的各向异性和区域间差异补充了先前对不同大脑解剖结构的力学特性的探索。
