Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
Department of Ophthalmology Neurosciences, Laboratory of Ophthalmology, KU Leuven, Leuven, Belgium.
Acta Ophthalmol. 2018 Sep;96(6):573-581. doi: 10.1111/aos.13818. Epub 2018 Oct 2.
To investigate the vitreopapillary interface (VPI) in health and glaucoma according to the different stages of posterior vitreous detachment (PVD) formation.
Prospective single centre study including healthy subjects and glaucoma patients. PVD staging was performed with spectral domain optical coherence tomography. Gender, age, lens status and refractive error were assessed in both groups. Glaucoma patients additionally had a comprehensive ophthalmological investigation including intraocular pressure measurement, visual field testing and confocal imaging of the optic nerve head.
Data on 523 subjects (993 eyes) were included from the VPI study (clinicaltrials.gov NCT02290795) database (493 eyes of 258 healthy subjects and 500 eyes of 265 glaucoma patients). Healthy subjects were significantly younger than primary open angle glaucoma patients (59.7 ± 14.81 versus 70.0 ± 10.78 years, p < 0.001), but were otherwise matched for refractive error and gender. Significantly more glaucomatous eyes were pseudophakic (26.6% versus 5.1%). Including only phakic nonoperated eyes from subjects between 50 and 80 years old decreased the age difference between healthy and open angle glaucoma (64.1 ± 8.0 versus 65.9 ± 6.7 years, p = 0.051). Comparing these subgroups rendered similar average ages for PVD stages 0 and 4, in contrast to the significant older age for the glaucoma subgroup in stage 1 (64.1 ± 6.01 versus 61.4 ± 8.38 years, p < 0.001) and a trend towards significance in stage 3 (70.8 ± 69.8 versus 67.5 ± 5.92 years, p = 0.051).
The VPI study is a large clinical trial investigating the VPI in health and glaucoma. A subset of glaucoma patients seems to experience stages 1-3 of PVD formation at older age compared to healthy subjects.
根据后玻璃体脱离（PVD）形成的不同阶段，研究健康眼和青光眼的玻璃体视网膜界面（VPI）。
这是一项包括健康受试者和青光眼患者的前瞻性单中心研究。使用谱域光相干断层扫描对 PVD 进行分期。两组均评估性别、年龄、晶状体状态和屈光不正。青光眼患者还进行了全面的眼科检查，包括眼压测量、视野测试和视神经头共焦成像。
从 VPI 研究（clinicaltrials.gov NCT02290795）数据库中纳入了 523 名受试者（993 只眼）的数据（258 名健康受试者的 493 只眼和 265 名青光眼患者的 500 只眼）。健康受试者明显比原发性开角型青光眼患者年轻（59.7 ± 14.81 岁比 70.0 ± 10.78 岁，p < 0.001），但其他方面的屈光不正和性别匹配。青光眼患者中明显更多的是人工晶状体眼（26.6%比 5.1%）。仅包括 50 至 80 岁之间的非手术未植入晶状体眼的受试者，减少了健康和开角型青光眼之间的年龄差异（64.1 ± 8.0 岁比 65.9 ± 6.7 岁，p = 0.051）。比较这些亚组，在 PVD 0 期和 4 期的平均年龄相似，但在 1 期，青光眼亚组的年龄明显较大（64.1 ± 6.01 岁比 61.4 ± 8.38 岁，p < 0.001），在 3 期有显著趋势（70.8 ± 69.8 岁比 67.5 ± 5.92 岁，p = 0.051）。
VPI 研究是一项大型临床试验，研究健康眼和青光眼的 VPI。与健康受试者相比，一部分青光眼患者似乎在较晚的年龄经历 PVD 形成的 1-3 期。
