Polymer Engineering Department, Faculty of Engineering, Urmia University, Urmia, Iran.
Color and Polymer Research Center (CPRC), Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Curr Stem Cell Res Ther. 2019;14(2):137-145. doi: 10.2174/1574888X13666181002152247.
It is next-to-impossible not to accept that cancer takes a position as the main cause of the global burden of disease, for it is hard to ignore the outnumbered people dying from cancer. Looking at the statistics proves that progress in cancer therapy is always beyond cancer in a race of pessimism about the future; for various kinds of cancers yearly cause death in the world, whereas the conventional and even modern therapies often exhibit lack of reliability in the treatment of cancer. In principle, various reasons are identified for cancer resistance and recurrence. Recognizing the cells/tissue from which cancer takes origin enables its early detection, and optimistically saying, protection of patients against death. It has been recognized that cancer stem cells are responsible for cancer cell proliferation and metastasis. Conventional therapies cannot eradicate the cancer stem cell; therefore, cancer recurrence is unavoidable. In this regards, designing smart platforms with specific properties is an essential step in cancer treatment. Theranostic platforms have facilitated the cancer diagnosis and treatment, simultaneously. In this respect, several types of smart materials have been designed to detect and cure cancer. Cancer stem cell as a root of the cancerous tumor should be eradicated to achieve the complete treatment; hence, cancer stem cell mechanism must be known precisely to design an appropriate platform making possible to encounter with cancer stem cell. In this review paper, various therapeutic and diagnostic techniques of cancerous stem cell are discussed to pave a way for designing proper platforms for cancer eradication.
几乎不可能不接受癌症是全球疾病负担的主要原因，因为很难忽视因癌症而死亡的人数众多。看看统计数据就可以证明，癌症治疗的进展总是超过对未来悲观主义的癌症；因为各种癌症每年都会导致世界范围内的死亡，而传统的甚至现代的疗法在癌症治疗中往往缺乏可靠性。原则上，已经确定了癌症耐药性和复发的各种原因。识别癌症起源的细胞/组织可以实现早期检测，并乐观地说，可以保护患者免受死亡。已经认识到癌症干细胞负责癌症细胞的增殖和转移。传统疗法不能根除癌症干细胞；因此，癌症复发是不可避免的。在这方面，设计具有特定特性的智能平台是癌症治疗的重要步骤。治疗诊断平台同时促进了癌症的诊断和治疗。在这方面，已经设计了几种类型的智能材料来检测和治疗癌症。癌症干细胞作为癌性肿瘤的根源，应该被根除，以实现完全治疗；因此，必须精确地了解癌症干细胞机制，以设计一个合适的平台，使其有可能遇到癌症干细胞。在这篇综述论文中，讨论了癌症干细胞的各种治疗和诊断技术，为设计适当的癌症根除平台铺平了道路。
