Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box: 31787-316 Tehran, Iran.
Polymer Engineering Department, Faculty of Engineering, Urmia University, P.O. Box: 5756151818-165 Urmia, Iran.
Biomolecules. 2019 Sep 4;9(9):448. doi: 10.3390/biom9090448.
Tissue engineering endeavors to regenerate tissues and organs through appropriate cellular and molecular interactions at biological interfaces. To this aim, bio-mimicking scaffolds have been designed and practiced to regenerate and repair dysfunctional tissues by modifying cellular activity. Cellular activity and intracellular signaling are performances given to a tissue as a result of the function of elaborated electrically conductive materials. In some cases, conductive materials have exhibited antibacterial properties; moreover, such materials can be utilized for on-demand drug release. Various types of materials ranging from polymers to ceramics and metals have been utilized as parts of conductive tissue engineering scaffolds, having conductivity assortments from a range of semi-conductive to conductive. The cellular and molecular activity can also be affected by the microstructure; therefore, the fabrication methods should be evaluated along with an appropriate selection of conductive materials. This review aims to address the research progress toward the use of electrically conductive materials for the modulation of cellular response at the material-tissue interface for tissue engineering applications.
组织工程旨在通过生物界面处适当的细胞和分子相互作用来再生组织和器官。为此，已经设计和实践了生物模拟支架，通过改变细胞活性来再生和修复功能失调的组织。细胞活性和细胞内信号转导是组织由于精心设计的导电材料的功能而表现出的性能。在某些情况下，导电材料表现出抗菌性能；此外，此类材料可用于按需药物释放。各种类型的材料，从聚合物到陶瓷和金属，已被用作导电组织工程支架的一部分，其导电性从半导电到导电的范围。细胞和分子活性也会受到微观结构的影响；因此，应该评估制造方法，并适当选择导电材料。本综述旨在探讨在组织工程应用中，为了调节材料-组织界面处的细胞反应，使用导电材料的研究进展。
