Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
Food Funct. 2018 Oct 17;9(10):5426-5435. doi: 10.1039/c8fo01431k.
This study investigated the effect of microencapsulated garlic and/or tomato on endothelial dysfunction induced by the PhenFlex test (PFT) in healthy male smokers. In a randomized, double-blind, placebo-controlled crossover trial, 41 healthy male smokers were randomly assigned to one of four groups to receive the test groups (in microencapsulated garlic powder, tomato extract and a mixture thereof) or the placebo group. Proteomic biomarkers related to endothelial integrity were measured in plasma. Microencapsulated garlic, tomato extract and the mixture affected endothelial integrity biomarkers differently. Garlic consumption increased prothrombin time and decreased SAA and IL-12. Tomato extract intake increased activated partial thrombin time and decreased d-dimer, SAA, sVCAM-1, IL-13 and MCP-3 levels. Consumption of the mixture increased sE-selectin and lowered D-dimer, SAA, IL-13 and IL-10 responses after PFT challenge for 6 h. The different responses became clearer under high compliance in the dietary restriction groups. This single-intake clinical trial addressed the different responses of biomarkers related to endothelial integrity.
本研究旨在探讨微胶囊化大蒜和/或番茄对健康男性吸烟者 PhenFlex 试验（PFT）诱导的内皮功能障碍的影响。在一项随机、双盲、安慰剂对照交叉试验中，41 名健康男性吸烟者被随机分为四组，分别接受试验组（微胶囊化大蒜粉、番茄提取物和混合物）或安慰剂组。在血浆中测量与内皮完整性相关的蛋白质组学生物标志物。微胶囊化大蒜、番茄提取物和混合物对内皮完整性生物标志物的影响不同。大蒜摄入增加了凝血酶原时间，降低了 SAA 和 IL-12。番茄提取物摄入增加了活化部分凝血酶时间，降低了 D-二聚体、SAA、sVCAM-1、IL-13 和 MCP-3 水平。在 PFT 挑战 6 小时后，混合物的摄入增加了 sE-选择素，并降低了 D-二聚体、SAA、IL-13 和 IL-10 的反应。在高依从性的饮食限制组中，这些不同的反应变得更加明显。这项单次摄入临床试验探讨了与内皮完整性相关的生物标志物的不同反应。
