Rohmer V, Saint-Andre J P, Alhenc-Gelas F, Corvol P, Bigorgne J C
Am J Clin Pathol. 1987 Feb;87(2):281-4. doi: 10.1093/ajcp/87.2.281.
High levels of angiotensin I-converting enzyme (ACE) were found by both direct radioimmunoassay and enzyme activity evaluation in a patient's plasma that had suprasellar germinoma. ACE levels returned to normal values after surgery, suggesting the tumor was the cause of the elevated plasma ACE. ACE was found in the tumor, and ACE activity was measured in a tumor extract. With the use of specific antihuman ACE antibodies, ACE was localized by immunohistochemistry in the tumoral germinal cells. Because ACE was also found in testicular germinomas, it appears to be a possible marker for germ cell tumors.
通过直接放射免疫测定法和酶活性评估发现，一名患有鞍上生殖细胞瘤患者的血浆中血管紧张素I转换酶（ACE）水平很高。术后ACE水平恢复到正常值，表明肿瘤是血浆ACE升高的原因。在肿瘤中发现了ACE，并在肿瘤提取物中测量了ACE活性。使用特异性抗人ACE抗体，通过免疫组织化学将ACE定位在肿瘤生发细胞中。由于在睾丸生殖细胞瘤中也发现了ACE，它似乎是生殖细胞肿瘤的一个可能标志物。
