Cotter T P, Kealy N P, Duggan P F, Curtain A, Bredin C P
Cork University Hospital, Ireland.
Respir Med. 1997 Apr;91(4):237-9. doi: 10.1016/s0954-6111(97)90045-7.
A case of a 32-year-old XY genotype female is described, presenting with mediastinal and abdominal lymphadenopathy and associated with an elevated serum angiotensin I converting enzyme (SACE) level. Lymph node histology showed a malignant dysgerminoma of ovarian origin. Combined chemotherapy led to a radiological regression of the lymphadenopathy and coincided with a decrease in SACE concentration. The authors suggest that SACE may be a marker for disseminated germinoma tumours and may be useful for monitoring treatment.
描述了一例32岁XY基因型女性病例，该患者出现纵隔和腹部淋巴结肿大，且血清血管紧张素I转换酶（SACE）水平升高。淋巴结组织学检查显示为卵巢来源的恶性无性细胞瘤。联合化疗导致淋巴结肿大在影像学上消退，同时SACE浓度降低。作者认为，SACE可能是播散性生殖细胞瘤肿瘤的一个标志物，可能有助于监测治疗。
