Saint-Andre J P, Alhenc-Gelas F, Rohmer V, Chretien M F, Bigorgne J C, Corvol P
Laboratoire d'Anatomie Pathologique, Centre Hospitalier Regional, Angers, France.
Hum Pathol. 1988 Feb;19(2):208-13. doi: 10.1016/s0046-8177(88)80351-4.
Angiotensin-I-converting enzyme (ACE) was detected in 18 germinomas, both of testicular or extratesticular localization, and studied by immunohistochemical methods using specific polyclonal antibodies and by enzyme activity measurements. ACE was also detected in normal human germ cells. On the other hand, it was not present in other types of testicular tumors. Biochemical studies and immunohistochemical findings suggest that at least part of the enzyme is membrane bound. Plasma ACE levels appeared to be normal, indicating that measurement of plasma ACE levels in germinomas would be of little help for the diagnosis and follow-up of patients. However, the apparent specificity of ACE detection in germinomas among germ cell tumors might help in histologic diagnosis, especially for tumors of extragonadal localization.
在18例生殖细胞瘤中检测到血管紧张素转换酶（ACE），这些生殖细胞瘤包括睾丸和睾丸外定位的肿瘤，并采用特异性多克隆抗体通过免疫组化方法以及酶活性测定进行研究。在正常人的生殖细胞中也检测到了ACE。另一方面，在其他类型的睾丸肿瘤中未检测到ACE。生化研究和免疫组化结果表明，该酶至少部分与膜结合。血浆ACE水平似乎正常，这表明测定生殖细胞瘤患者的血浆ACE水平对诊断和随访帮助不大。然而，ACE在生殖细胞肿瘤中生殖细胞瘤检测的明显特异性可能有助于组织学诊断，特别是对于性腺外定位的肿瘤。
