Elson C J, Sullivan C P
Immunology. 1977 Sep;33(3):369-72.
The duration of the inductive effect of an antigen (alum-precipitated trinitrophenyl-keyhole limpet haemocyanin) was measured, in the presence and absence of responding spleen cells, by transfering a test population of spleen cells to irradiated mice at various times relative to antigen injection. Using allotype-congenic mice, the response of a test (Iga) population was estimated in the presence of responding (Igb) cells. In the absence of responding cells the inductive effect fell to 10% of the peak value in 9-10 days, but in their presence it reached this level in less than 5 days. Removal of T cells from the responding (Igb) population reduced their suppressive efficacy. It was concluded that B lymphocyte recruitment is curtailed not by the elimination of antigen but by an active suppressor mechanism involving suppressor T cells.
通过在相对于抗原注射的不同时间，将测试脾细胞群体转移到受辐照小鼠体内，在有和没有反应性脾细胞存在的情况下，测量抗原（明矾沉淀的三硝基苯基-钥孔血蓝蛋白）诱导效应的持续时间。使用同种异型同基因小鼠，在有反应性（Igb）细胞存在的情况下估计测试（Iga）群体的反应。在没有反应性细胞的情况下，诱导效应在9-10天内降至峰值的10%，但在有反应性细胞存在的情况下，不到5天就达到了这个水平。从反应性（Igb）群体中去除T细胞会降低它们的抑制效力。得出的结论是，B淋巴细胞募集不是通过抗原的消除而是通过涉及抑制性T细胞的主动抑制机制而受到限制。
