绵羊红细胞对大鼠淋巴细胞募集的诱导作用持续时间。
Duration of the inductive effect of sheep erythrocytes on the recruitment of lymphocytes in the rat.
作者信息
Ford W L
出版信息
Immunology. 1968 Oct;15(4):609-17.
Abstract
The serum haemolysin response was studied in rats which had been subjected to a suppressive whole-body dose of γ-irradiation followed after 24 hours by an intravenous injection of sheep erythrocytes. A standard restorative dose of syngeneic thoracic duct lymphocytes was given immediately after the antigen or after a variable delay. Delays of 12, 24, 48 and 72 hours were followed by progressively smaller haemolysin responses. These observations suggested that the recruitment of lymphocytes begins very soon after the injection of sheep erythrocytes and that the inductive influence of the antigen wanes steadily so that the effective period of recruitment probably lasts for 1–2 days.
摘要
在接受全身抑制剂量γ射线照射的大鼠中研究血清溶血素反应，24小时后静脉注射绵羊红细胞。在注射抗原后或经过不同时间延迟后，立即给予标准剂量的同基因胸导管淋巴细胞进行恢复。延迟12、24、48和72小时后，溶血素反应逐渐减弱。这些观察结果表明，在注射绵羊红细胞后不久淋巴细胞募集就开始了，并且抗原的诱导作用稳步减弱，因此募集的有效时间可能持续1-2天。
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