Shoho Yoshifumi, Kimura Takao, Yanagawa Yoshimaro, Saito Ai, Inoue Toshiya, Suto Chiaki, Tsunekawa Katsuhiko, Araki Osamu, Nara Makoto, Tokue Yutaka, Murakami Masami
Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine.
Department of Childcare, Ikuei Junior College.
Tohoku J Exp Med. 2018 Oct;246(2):73-79. doi: 10.1620/tjem.246.73.
In 2014, for the protection of medical workers against measles and rubella infection, the Japanese Society for Infection Prevention and Control (JSIPC) recommended either maintaining antibody titers of seroprotective range or two-dose vaccination. JSIPC defined antibody titers into 3 ranges: seroprotective as expected prevention of infection, seronegative as under detection levels, and seropositive as antibody titers ranged between seronegative and seroprotective. This study aimed to explore the association between the number of vaccine doses received and the antibody titers against measles and rubella among Japanese college students majoring in childcare. A total of 841 female students with no history of measles or rubella were serologically screened at the time of college admission between 2015 and 2018. All 841 students had been vaccinated against measles; 738 (87.8%) received two doses of the measles vaccine and 103 (12.2%) received one dose. Likewise, 839 students, except for two, had been vaccinated against rubella; 719 (85.7%) received two doses of the rubella vaccine and 120 (14.3%) received one dose. We thus found that 107 students (12.7%) were seropositive for measles-specific IgG and 731 (86.9%) attained seroprotective titers. By contrast, in case of rubella-specific IgG, only 462 students (55.1%) attained seroprotective titers, and 371 students (44.1%) were seropositive. The two students without receiving rubella vaccination were classified as seronegative. In conclusion, despite that > 85% of students surveyed had received two doses of measles and rubella vaccines, a substantial number of students remain susceptible to measles and especially rubella at the time of college admission.
2014年，为保护医护人员免受麻疹和风疹感染，日本感染预防与控制协会（JSIPC）建议维持血清保护范围内的抗体滴度或接种两剂疫苗。JSIPC将抗体滴度分为3个范围：血清保护型为预期可预防感染，血清阴性为低于检测水平，血清阳性为抗体滴度介于血清阴性和血清保护型之间。本研究旨在探讨日本幼儿保育专业大学生接种疫苗的剂量数与麻疹和风疹抗体滴度之间的关联。2015年至2018年大学入学时，对841名无麻疹或风疹病史的女学生进行了血清学筛查。所有841名学生均接种过麻疹疫苗；738名（87.8%）接种了两剂麻疹疫苗，103名（12.2%）接种了一剂。同样，除两名学生外，839名学生接种过风疹疫苗；719名（85.7%）接种了两剂风疹疫苗，120名（14.3%）接种了一剂。我们发现，107名学生（12.7%）麻疹特异性IgG呈血清阳性，731名（86.9%）达到血清保护滴度。相比之下，对于风疹特异性IgG，只有462名学生（55.1%）达到血清保护滴度，371名学生（44.1%）呈血清阳性。两名未接种风疹疫苗的学生被归类为血清阴性。总之，尽管超过85%的受调查学生接种了两剂麻疹和风疹疫苗，但仍有相当数量的学生在大学入学时对麻疹尤其是风疹易感。
