Davis P, Johnston C, Bertouch J, Starkebaum G
Ann Rheum Dis. 1987 Jan;46(1):51-4. doi: 10.1136/ard.46.1.51.
Neutrophils of 31 patients with neutropenia and rheumatoid arthritis (RA) have been studied to assess their ability to generate superoxide radicals (O-2) on activation. Seventeen patients had classical Felty's syndrome and 14 presumed chrysotherapy related neutropenia. Results were compared with those from age and sex matched controls with uncomplicated RA and from normal subjects. Neutrophils from patients with Felty's syndrome had a significantly reduced ability to generate superoxide radicals when compared with the other three groups. In addition, serum levels of IgG polymorphonuclear leucocyte binding activity (IgG PBA) were also raised in the group with Felty's syndrome. A statistically significant inverse correlation existed between O-2 generation and IgG PBA. It is concluded that neutrophil reactive IgG may have an important role in both quantitative and qualitative defects in neutrophil function in Felty's syndrome.
对31例中性粒细胞减少症合并类风湿关节炎（RA）患者的中性粒细胞进行了研究，以评估其激活后产生超氧阴离子自由基（O-2）的能力。17例患者患有典型的费尔蒂综合征，14例推测为金疗法相关的中性粒细胞减少症。将结果与年龄和性别匹配的无并发症RA对照组以及正常受试者的结果进行比较。与其他三组相比，费尔蒂综合征患者的中性粒细胞产生超氧阴离子自由基的能力显著降低。此外，费尔蒂综合征组的血清免疫球蛋白G多形核白细胞结合活性（IgG PBA）水平也升高。O-2生成与IgG PBA之间存在统计学上显著的负相关。结论是，中性粒细胞反应性IgG可能在费尔蒂综合征中性粒细胞功能的数量和质量缺陷中起重要作用。
