Priest N D, Jackson S
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Oct;32(4):325-50. doi: 10.1080/09553007714551091.
Plutonium-241 citrate solution at pH 6-5 was injected intravenously into hamsters and an adult rabbit at a dose of 10 kBq g-1 (260 nCi g-1). The hamsters were killed serially at 15 min, 2 hours, 1 day, 10 days, 1 month and 6 months after injection and the rabbit at 1 week. Their knee-joints or femora were examined for plutonium-241 by autoradiography. Few differences were found between the pattern of plutonium distribution in the hamsters and the rabbit. The results showed that although plutonium is initially distributed on bone surfaces, at long periods after injection it becomes deposited throughout the bone matrix. Plutonium uptake by cells in resorbing areas of periosteum, in active osteoblasts, and in chondrocytes in regions of cartilage mineralization was rapid. Plutonium concentrated more slowly on the resting bone surfaces and at sites of low metabolic activity. In addition, some unlabelled sections of skeletal tissues were immersed in a plutonium-241 citrate solution. When autoradiographed, it was found that plutonium was bound by cell nuclei, tooth enamel matrix, dentine, predentine and bone matrix. Plutonium binding to cartilage matrix was weak. The results are discussed with reference to the literature, and a model is proposed to explain the distribution pattern and fate of plutonium deposits in bone.
将pH值为6至5的柠檬酸钚-241溶液以10 kBq g-1（260 nCi g-1）的剂量静脉注射到仓鼠和一只成年兔子体内。仓鼠在注射后15分钟、2小时、1天、10天、1个月和6个月分批处死，兔子在1周后处死。通过放射自显影检查它们的膝关节或股骨中的钚-241。在仓鼠和兔子体内钚的分布模式之间几乎没有发现差异。结果表明，虽然钚最初分布在骨表面，但在注射后的很长一段时间内，它会沉积在整个骨基质中。在骨膜吸收区域的细胞、活跃的成骨细胞以及软骨矿化区域的软骨细胞中，钚的摄取很快。钚在静止的骨表面和低代谢活性部位的聚集速度较慢。此外，将一些未标记的骨骼组织切片浸入柠檬酸钚-241溶液中。进行放射自显影时发现，钚与细胞核、牙釉质基质、牙本质、前期牙本质和骨基质结合。钚与软骨基质的结合较弱。结合文献对结果进行了讨论，并提出了一个模型来解释钚在骨中的沉积分布模式和归宿。
