钚-214在啮齿动物体内的分布。

The distribution of plutonium-214 in rodents.

作者信息

Priest N D

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Jan;31(1):59-78. doi: 10.1080/09553007714550061.

Abstract

Plutonium-214 citrate solution at pH 6-5 was injected intravenously or intra-peritoneally into hamsters and rats at a dose of 50 MBq kg-1 (1-35 mCi kg-1). The animals were killed 1 day or 1 week later, and tissues were removed for autoradiography and radiochemical analysis. Plutonium-241 was distributed in rats in the same way as plutonium-239, and is a suitable isotope for high-resolution tissue-section autoradiography. Plutonium deposits in cells consisted of a nuclear and a cytoplasmic component. In the hamster kidney cells, the amount associated with the nucleus was about 55 per cent of the total cellular plutonium at 24 hours after injection. Six days later, it was only about 30 per cent. Plutonium deposits were also characterized in hepatocytes, in the interstitial cells of the testes, in the cells of ovarian follicles, in chondrocytes and in bone cells, including osteoblasts and osteocytes. In bone there appeared to be both an extracellular and intracellular deposit. No evidence was found of substantial incorporation of plutonium into the mineral phase of bone.

摘要

将pH值为6至5的柠檬酸钚-214溶液以50 MBq kg⁻¹（1至35 mCi kg⁻¹）的剂量静脉内或腹腔内注射到仓鼠和大鼠体内。1天或1周后处死动物，并取出组织进行放射自显影和放射化学分析。钚-241在大鼠体内的分布方式与钚-239相同，是用于高分辨率组织切片放射自显影的合适同位素。钚在细胞中的沉积由核成分和细胞质成分组成。在仓鼠肾细胞中，注射后24小时与细胞核相关的量约占细胞内钚总量的55%。6天后，仅约为30%。钚的沉积在肝细胞、睾丸间质细胞、卵巢卵泡细胞、软骨细胞和骨细胞（包括成骨细胞和骨细胞）中也有特征。在骨骼中似乎既有细胞外沉积也有细胞内沉积。未发现钚大量掺入骨矿物质相的证据。