Department of Epidemiology, National Institute for Infectious Diseases 'L. Spallanzani', Rome, Italy.
Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
Genes Immun. 2019 Jul;20(6):509-513. doi: 10.1038/s41435-018-0047-7. Epub 2018 Oct 4.
Skin melanoma remains one of the most aggressive and difficult to treat human malignancy, with an increasing incidence every year. Although surgical resection represents the best therapeutic approach, this is only feasible in cases of early diagnosis. Furthermore, the established malignancy is resistant to all therapeutic strategies employed so far, resulting in an unacceptable patient survival rate. Although the immune-mediated therapeutic approaches, based on anti-PD1 or anti-CTLA4, are very promising and under clinical trial experimentation, they could conceal not yet fully emerged pitfalls such as the development of autoimmune diseases. Therefore, alternative therapeutic approaches are still under investigation, such as the immunogenic cell death (ICD) process. Here we show that the lack of calreticulin translocation onto mouse melanoma cell membrane prevents the stimulation of an effective ICD response in vivo.
皮肤黑色素瘤仍然是最具侵袭性和最难治疗的人类恶性肿瘤之一，其发病率每年都在增加。尽管手术切除是最好的治疗方法，但只有在早期诊断的情况下才可行。此外，已确立的恶性肿瘤对迄今为止使用的所有治疗策略都具有抗性，导致患者的生存率不可接受。尽管基于抗 PD1 或抗 CTLA4 的免疫介导的治疗方法非常有前途，并且正在临床试验中进行实验，但它们可能隐藏了尚未完全出现的陷阱，例如自身免疫性疾病的发展。因此，仍在研究替代治疗方法，例如免疫原性细胞死亡（ICD）过程。在这里，我们表明钙网蛋白向小鼠黑色素瘤细胞膜的转位缺失会阻止体内有效的 ICD 反应的刺激。
