Centre for Fish and Wildlife Health (FIWI), Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, 3001, Bern, Switzerland.
Info fauna Karch, UniMail, Batiment G, Bellevaux 51, 2000, Neuchâtel, Switzerland.
Sci Rep. 2018 Oct 3;8(1):14737. doi: 10.1038/s41598-018-32841-0.
Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at different and distant locations. The virus is found in the skin and occasionally in the brain of infected toads. The genome of the virus is at least 158 Kb long and contains at least 152 open reading frames with a minimal length of 270 nt. The genome of BfHV1 contains all the signature genes that are present in alloherpesviruses. Phylogenetic analysis based on the amino acid sequence of the DNA polymerase and terminase proteins positions the novel virus among the members of the genus Batrachovirus, family Alloherpesviridae. This is the first herpesvirus ever characterized in common toads.
在这里，我们报告了一种新型疱疹病毒的发现和部分特征，该病毒暂定名为Bufonid 疱疹病毒 1（BfHV1），源自瑞士自由放养的普通蟾蜍（Bufo bufo）的严重皮炎。自 2014 年以来，每年春季交配季节，在不同和遥远的地点，都观察到这种疾病在蟾蜍中发生。该病毒存在于受感染蟾蜍的皮肤中，偶尔也存在于大脑中。该病毒的基因组至少有 158 Kb 长，包含至少 152 个开放阅读框，最小长度为 270 nt。BfHV1 的基因组包含所有存在于 alloherpesviruses 中的特征基因。基于 DNA 聚合酶和末端酶蛋白的氨基酸序列进行的系统发育分析将新型病毒定位在 Batrachovirus 属和 Alloherpesviridae 科的成员中。这是首次在普通蟾蜍中鉴定出疱疹病毒。
