Floch Aline, Tournamille Christophe, Chami Btissam, Pirenne France
Etablissement Français du Sang (EFS) - Ile de France, Créteil, France.
INSERM U955, Equipe 2 'Transfusion et maladies du globule rouge', Créteil, France.
Transfus Med Hemother. 2018 Jul;45(4):264-270. doi: 10.1159/000490858. Epub 2018 Jul 6.
This review presents the French strategy for blood group genotyping in high-responder and newly diagnosed sickle cell disease (SCD) patients. In addition to , , and genotyping, the RH blood group system is now explored in SCD patients in France. Molecular typing has been used for the deduction of partial RH2 (C) antigens since 2010, and the gradual implementation of systematic and genotyping nationwide was initiated in late 2014. In our laboratory, 962 RH:2 (C-positive) SCD patients have been tested since 2010, and 1,148 SCD patients of all RH phenotypes have been genotyped for clinically relevant alleles of and since late 2014.
本综述介绍了法国针对高反应性和新诊断的镰状细胞病（SCD）患者进行血型基因分型的策略。除了 、 和 基因分型外，法国目前还在SCD患者中探索RH血型系统。自2010年以来，分子分型已用于推断部分RH2（C）抗原，2014年末开始在全国逐步实施系统性的 和 基因分型。自2010年以来，我们实验室已对962例RH:2（C阳性）SCD患者进行了检测，自2014年末以来，已对1148例所有RH表型的SCD患者进行了 和 临床相关等位基因的基因分型。
