沙特阿拉伯一家大型三级医院的药品不良反应报告：一项激励策略的结果
Adverse drug reaction reporting in a large tertiary hospital in Saudi Arabia: results of an incentive strategy.
作者信息
Ali Sheraz, Egunsola Oluwaseun, Al-Dossari Dalal Salem, Al-Zaagi Ibrahim Abdulaziz
机构信息
King Saud Medical City, Ministry of Health, Al Imam Turki Ibn Abdullah Ibn Muhammad, Ulaishah, 12746, Riyadh, Saudi Arabia.
Clinical Pharmacology and Toxicology Research Group, Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, The University of Sydney, NSW, Australia.
出版信息
Ther Adv Drug Saf. 2018 Aug 11;9(10):585-590. doi: 10.1177/2042098618790209. eCollection 2018 Oct.
BACKGROUND
Underreporting is a common problem with spontaneous adverse drug reaction (ADR) reporting. In this study, we aim to describe the reporting of ADRs in a tertiary hospital and determine the effect of incentives to healthcare professionals on ADR reporting.
METHODS
In this interventional study, a time series analysis was used to determine the effect of incentives on ADR reporting in a tertiary hospital between 2015 and 2016. The incentive strategy included public commendation of health care providers and nomination for a monthly award.
RESULTS
A total of 967 ADRs were reported over a 2-year period. After the introduction of incentives in January 2016, the number of ADR reports per month increased by 40.6 (95% confidence interval: 26.1-55.1). The proportion of serious ADRs reported was significantly higher in 2016 (39/800) than 2015 (0/167) ( < 0.001). In 2016, there was a significant association between profession and serious ADR reporting ( < 0.001). A total of 14/21 ADRs (66.7%) reported by physicians in 2016 were serious compared with 20/700 (2.9%) reported by clinical pharmacists and 5/72 (6.9%) by nurses.
CONCLUSIONS
ADR reporting was improved by providing incentives, including commendation and reward, to healthcare professionals.
背景
漏报是自发药物不良反应（ADR）报告中的常见问题。在本研究中，我们旨在描述一家三级医院的ADR报告情况，并确定对医护人员的激励措施对ADR报告的影响。
方法
在这项干预性研究中，采用时间序列分析来确定2015年至2016年期间激励措施对一家三级医院ADR报告的影响。激励策略包括对医护人员的公开表扬和月度奖励提名。
结果
在两年期间共报告了967例ADR。2016年1月引入激励措施后，每月ADR报告数量增加了40.6例（95%置信区间：26.1 - 55.1）。2016年报告的严重ADR比例（39/800）显著高于2015年（0/167）（P < 0.001）。2016年，职业与严重ADR报告之间存在显著关联（P < 0.001）。2016年医生报告的21例ADR中有14例（66.7%）为严重ADR，而临床药师报告的700例中有20例（2.9%），护士报告的72例中有5例（6.9%）。
结论
通过向医护人员提供表扬和奖励等激励措施，ADR报告情况得到了改善。
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