Department of Chemistry, Department of Physics and Astronomy, Department of Pharmacology, and the Department of Chemical and Biomolecular Engineering, and Vanderbilt Institute of Nanoscale Science and Engineering Vanderbilt Institute of Chemical Biology , Vanderbilt University , Nashville , Tennessee 37235 , United States.
ACS Chem Neurosci. 2019 Jan 16;10(1):30-32. doi: 10.1021/acschemneuro.8b00495. Epub 2018 Oct 4.
Quantum dots are nanometer-sized semiconductors that have size-tunable, narrow emission bands, high quantum yields, and are resistant to photobleaching. Ligand-conjugated quantum dots enable the real time visualization of membrane proteins and have revealed that membrane diffusion dynamics are intrinsic to protein regulation, are susceptible to the level of membrane cholesterol, and are altered in genetic variants linked to disease, suggesting a mise en place approach to neuropsychopharmacology.
量子点是纳米级半导体，具有可调尺寸、窄发射带、高量子产率和抗光漂白性。配体共轭量子点能够实时可视化膜蛋白，并揭示了膜扩散动力学是蛋白质调节的固有特性，易受膜胆固醇水平的影响，并且在与疾病相关的遗传变异中发生改变，这表明神经精神药理学的一种准备方法。
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