Department of Chemistry, School of Science, and Xi'an Key Laboratory of Sustainable Energy Materials Chemistry , Xi'an Jiaotong University , Xi'an 710049 , P. R. China.
Org Lett. 2018 Oct 19;20(20):6559-6563. doi: 10.1021/acs.orglett.8b02898. Epub 2018 Oct 4.
A sustainable strategy by internally recycling an organocatalyst as a reactant in a downstream reaction to improve the atom efficiency of organocatalytic tandem reactions is described. Specifically, a one-pot tandem Cloke-Wilson/Boulton-Katritzky reaction of cyclopropylketones with a hydroxylamine has been developed for the synthesis of fully substituted isoxazoles, in which the hydroxylamine serves as both an upstream catalyst and a downstream reactant.
描述了一种通过在下游反应中将有机催化剂内部回收作为反应物来提高有机催化串联反应原子效率的可持续策略。具体来说，开发了一种一锅法串联 Cloke-Wilson/Boulton-Katritzky 反应，用于环丙基酮与羟胺的反应，以合成全取代的异恶唑，其中羟胺既作为上游催化剂又作为下游反应物。
