Chemical Sciences Division, Indian Institute of Petroleum, Dehradun, India 248005.
Org Biomol Chem. 2011 Oct 21;9(20):6943-8. doi: 10.1039/c1ob05818e. Epub 2011 Sep 1.
The utility of thiourea dioxide as an efficient organocatalyst for the library synthesis of novel heterocyclic compounds via one-pot multicomponent coupling reactions is disclosed. Thiourea dioxide is an inexpensive and readily accessible catalyst, resulting in better product yields as compared to the corresponding thiourea as catalyst. Thiourea dioxide is found to be insoluble in various organic solvents and therefore at the end of the reaction products can be separated by extraction with diethyl ether and the recovered catalyst can be used several times with consistent catalytic activity.
本文介绍了二硫代亚磺酸作为一种高效的有机催化剂，用于通过一锅多组分偶联反应库合成新型杂环化合物。二硫代亚磺酸是一种廉价且易于获得的催化剂，与相应的硫脲作为催化剂相比，产物产率更高。二硫代亚磺酸不溶于各种有机溶剂，因此反应结束后，可以用乙醚萃取分离产物，回收的催化剂可以重复使用多次，具有一致的催化活性。
