Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Biosci Rep. 2019 Apr 5;39(4). doi: 10.1042/BSR20181582. Print 2019 Apr 30.
polymorphisms have been reported to correlate with an increased susceptibility to a few types of cancers, although their role in neuroblastoma has not yet been clarified. We investigated the association between three single polymorphisms (rs2839698 G>A, rs3024270 C>G, and rs217727 G>A) and neuroblastoma susceptibility in Chinese Han populations. Three hundred ninety-three neuroblastoma patients and 812 healthy controls were enrolled from the Henan and Guangdong provinces. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to determine the strength of the association of interest. Separated and combined analyses revealed no associations of the rs2839698 G>A, rs3024270 C>G or rs217727 G>A polymorphisms and neuroblastoma susceptibility. In the stratification analysis, female children with rs3024270 GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.61, 95% CI = 1.04-2.50, =0.032). The rs3024270 GG genotype might contribute to an increased neuroblastoma susceptibility in female Chinese children.
多态性已被报道与一些类型的癌症易感性增加相关，尽管它们在神经母细胞瘤中的作用尚未阐明。我们研究了三个单核苷酸多态性（rs2839698 G>A、rs3024270 C>G 和 rs217727 G>A）与中国汉族人群神经母细胞瘤易感性之间的关系。从河南省和广东省招募了 393 名神经母细胞瘤患者和 812 名健康对照者。比值比（ORs）和 95%置信区间（CIs）用于确定相关关联的强度。单独和联合分析均未发现 rs2839698 G>A、rs3024270 C>G 或 rs217727 G>A 多态性与神经母细胞瘤易感性之间存在关联。在分层分析中，携带 rs3024270 GG 基因型的女性儿童神经母细胞瘤发病风险增加（校正 OR=1.61，95%CI=1.04-2.50，=0.032）。rs3024270 GG 基因型可能导致中国女性儿童神经母细胞瘤易感性增加。
