埃塞俄比亚西北部贡德尔镇医疗中心结核病患者的抗结核治疗不依从情况、原因及相关因素
Non-adherence to anti-tuberculosis treatment, reasons and associated factors among TB patients attending at Gondar town health centers, Northwest Ethiopia.
作者信息
Mekonnen Habtamu Sewunet, Azagew Abere Woretaw
机构信息
Department of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
BMC Res Notes. 2018 Oct 1;11(1):691. doi: 10.1186/s13104-018-3789-4.
OBJECTIVE
The aim of this study was to assess the prevalence of non-adherence to anti-tuberculosis treatment, reasons and associated factors among TB patients attending at Gondar town health centers.
RESULT
A total of 314 participants were included with the response rate of 97.5%. The mean age of participants was 35.94 (SD ± 13.83) years. The overall rate of non-adherence to anti-TB treatment was 21.2% (95% CI 17.2, 26.1). Continuation phase of treatment (AOR = 2.27, 95% CI (1.54, 5.94)), presence of more than one co-morbidity (AOR = 6.22; 95% CI (2.21, 17.48)), poor knowledge about TB and anti-TB therapy (AOR = 4.11; 95% CI 1.57, 10.75), poor patient-provider relationship (AOR = 4.60, 95% CI 1.63, 12.97), and alcohol intake (AOR = 5.03; 95% CI 1.54, 16.40) were significantly associated with non-adherence. Forgetting 40 (23.1%), Being busy with other work 35 (20.2%), and being out of home/town 24 (13.9%) were the major reasons of participants for interruption of taking anti-TB medications.
目的
本研究旨在评估贡德尔镇医疗中心结核病患者中抗结核治疗不依从的患病率、原因及相关因素。
结果
共纳入314名参与者，应答率为97.5%。参与者的平均年龄为35.94（标准差±13.83）岁。抗结核治疗的总体不依从率为21.2%（95%置信区间17.2, 26.1）。治疗的继续阶段（调整后比值比=2.27，95%置信区间(1.54, 5.94)）、存在一种以上合并症（调整后比值比=6.22；95%置信区间(2.21, 17.48)）、对结核病和抗结核治疗知识了解不足（调整后比值比=4.11；95%置信区间1.57, 10.75）、医患关系不佳（调整后比值比=4.60，95%置信区间1.63, 12.97）以及饮酒（调整后比值比=5.03；95%置信区间1.54, 16.40）与不依从显著相关。忘记服药40例（23.1%）、忙于其他工作35例（20.2%）以及外出/不在镇上24例（13.9%）是参与者中断服用抗结核药物的主要原因。
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