Hunan Provincial People's Hospital, Children's Medical Center, Changsha, China.
Key Laboratory for Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.
J Med Virol. 2019 Mar;91(3):392-400. doi: 10.1002/jmv.25333. Epub 2018 Oct 28.
To investigate the current genotypes of circulating human adenovirus (HAdV) strains, we molecularly genotyped HAdV in the nasopharyngeal aspirates (NPAs) of patients with acute lower respiratory tract infections (ALRTIs) and attempted to determine their associations with clinical symptoms. A total of 4751 NPA samples were collected from 4751 patients admitted to Hunan Provincial People's Hospital from September 2007 to March 2014, of which 447 (9.4%) samples were HAdV positive. Fourteen different HAdV types were identified; HAdV types 1 to 7 (HAdV 1-7) were identified in 95.7% of the 447 NPA samples with HAdV-7 and HAdV-3 being the most prevalent. In addition, 93.3% (417 of 447) of patients were younger than 5 years. The incidence of HAdV infection peaked in summer. Different HAdV types showed a predilection for different age groups and different seasonal distribution patterns. Coinfection of HAdVs and other respiratory viruses was detected in 63.3% (283 of 447) of the HAdV-positive samples. The most common clinical diagnosis was pneumonia and the most common symptoms were fever and cough. In comparison with children infected with HAdV-3 alone, those infected with HAdV-7 alone had an increased frequency of severe pneumonia involvement (11.6% vs 32.4%; P = 0.031), higher intensive care unit admission rates (7.0% vs 26.5%; P = 0.019), and a longer length of hospital stay (P = 0.03). Mixed infections in younger children were associated with a longer hospital stay (P = 0.023). Our results demonstrate the recent changes in the trends of circulating HAdV genotypes associated with ALRTIs in Hunan China.
为了研究目前流行的人腺病毒（HAdV）株的基因型，我们对急性下呼吸道感染（ALRTI）患者的鼻咽抽吸物（NPA）中的 HAdV 进行了分子基因分型，并试图确定其与临床症状的关系。我们从 2007 年 9 月至 2014 年 3 月期间湖南省人民医院收治的 4751 例患者中采集了 4751 份 NPA 样本，其中 447（9.4%）份样本 HAdV 阳性。共鉴定出 14 种不同的 HAdV 型；在 447 份 HAdV-NPA 样本中，95.7%（417 份）鉴定出 HAdV 1-7 型，其中 HAdV-7 和 HAdV-3 最为常见。此外，93.3%（417 例）的患者年龄小于 5 岁。HAdV 感染的发病率在夏季达到高峰。不同的 HAdV 型与不同年龄组和不同季节分布模式有关。在 447 份 HAdV 阳性样本中，检测到 63.3%（283 份）存在 HAdV 与其他呼吸道病毒的混合感染。最常见的临床诊断是肺炎，最常见的症状是发热和咳嗽。与单独感染 HAdV-3 的儿童相比，单独感染 HAdV-7 的儿童重症肺炎的发生率更高（11.6%比 32.4%；P=0.031），重症监护病房的入住率更高（7.0%比 26.5%；P=0.019），住院时间更长（P=0.03）。年龄较小的儿童混合感染与住院时间延长有关（P=0.023）。我们的研究结果表明，在中国湖南，与急性下呼吸道感染相关的循环 HAdV 基因型的流行趋势最近发生了变化。
