Shin Sun Ah, Na Hee Young, Choe Ji Young, Chung Doohyun, Park Mira, Oh Sohee, Kim Ji Eun
Department of Pathology, Seoul National University Hospital, Seoul, Korea.
Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
J Pathol Transl Med. 2018 Nov;52(6):357-362. doi: 10.4132/jptm.2018.09.13. Epub 2018 Oct 4.
The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of this study was to examine the expression levels of adipophilin and related hypoxic signaling proteins and to determine their prognostic impacts and associations with the pathologic characteristics of lung adenocarcinoma.
Expression levels of adipophilin, heat shock protein 27 (HSP27), carbonic anhydrase IX, and hypoxia-inducible factor 1α were examined by immunohistochemical staining using tissue microarray blocks. Correlations between protein expression levels and various clinicopathologic features were analyzed.
A total of 230 cases of primary adenocarcinoma of the lung were enrolled in this study. Adipophilin expression was more frequent in males and with the solid histologic type. It was correlated with HSP27 expression. Patients with adipophilin-positive adenocarcinoma showed a shorter progression-free survival (PFS) (median PFS, 17.2 months vs 18.4 months) in a univariable survival analysis, whereas HSP27 positivity correlated with favorable overall survival (OS) and PFS. In a multivariable analysis, adipophilin and HSP27 were independent prognostic markers of both OS and PFS.
Activated lipid metabolism and the hypoxic signaling pathway might play a major role in the progression of lung adenocarcinoma, especially in the solid histologic type.
在许多类型的恶性肿瘤中都有脂生成途径上调的报道。然而，其致病作用或临床意义尚未完全明确。本研究的目的是检测脂联素及相关缺氧信号蛋白的表达水平，并确定它们对肺腺癌的预后影响以及与病理特征的相关性。
使用组织微阵列芯片通过免疫组织化学染色检测脂联素、热休克蛋白27（HSP27）、碳酸酐酶IX和缺氧诱导因子1α的表达水平。分析蛋白表达水平与各种临床病理特征之间的相关性。
本研究共纳入230例原发性肺腺癌病例。脂联素表达在男性及实体组织学类型中更为常见。它与HSP27表达相关。在单变量生存分析中，脂联素阳性腺癌患者的无进展生存期（PFS）较短（中位PFS，17.2个月对18.4个月），而HSP27阳性与良好的总生存期（OS）和PFS相关。在多变量分析中，脂联素和HSP27是OS和PFS的独立预后标志物。
激活的脂质代谢和缺氧信号通路可能在肺腺癌的进展中起主要作用，尤其是在实体组织学类型中。
