3D 基因组浏览器：一个用于可视化 3D 基因组组织和长距离染色质相互作用的基于网络的浏览器。
The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions.
机构信息
Bioinformatics and Genomics Program, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Department of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State Hershey, Hershey, PA, 17033, USA.
出版信息
Genome Biol. 2018 Oct 4;19(1):151. doi: 10.1186/s13059-018-1519-9.
Here, we introduce the 3D Genome Browser, http://3dgenome.org , which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types. We design a new binary data format for Hi-C data that reduces the file size by at least a magnitude and allows users to visualize chromatin interactions over millions of base pairs within seconds. Our browser provides multiple methods linking distal cis-regulatory elements with their potential target genes. Users can seamlessly integrate thousands of other omics data to gain a comprehensive view of both regulatory landscape and 3D genome structure.
在这里，我们介绍 3D 基因组浏览器，http://3dgenome.org，它允许用户方便地探索他们自己的和超过 300 种不同类型的公开染色质相互作用数据。我们为 Hi-C 数据设计了一种新的二进制数据格式，将文件大小至少减少一个数量级，并允许用户在几秒钟内可视化跨越数百万个碱基对的染色质相互作用。我们的浏览器提供了多种方法将远端顺式调控元件与其潜在的靶基因联系起来。用户可以无缝集成数千种其他组学数据，以全面了解调控景观和 3D 基因组结构。
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