患有化脓性汗腺炎的患者中寻常痤疮的总体患病率和亚组患病率。

Overall and subgroup prevalence of acne vulgaris among patients with hidradenitis suppurativa.

机构信息

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

出版信息

J Am Acad Dermatol. 2019 May;80(5):1308-1313. doi: 10.1016/j.jaad.2018.09.040. Epub 2018 Oct 1.

DOI:10.1016/j.jaad.2018.09.040

PMID:30287328

Abstract

BACKGROUND

Evidence establishing a link between acne vulgaris (AV) and hidradenitis suppurativa (HS) is limited, and the burden of AV in adults with HS is unknown.

OBJECTIVE

To determine the prevalence of AV among adults with HS and determine the strength of this association.

METHODS

Cross-sectional analysis identifying adults with AV among patients with and without HS by using electronic health record data from a population-based sample of more than 55 million patients.

RESULTS

The prevalence of AV among adults with HS was 15.2% (7315 of 48,085) compared with 2.9% (497,360 of 16,899,470) for adults without HS (P < .001). The prevalence was greatest among patients with HS who were female (5870 of 35,790 [16.4%]), were 18 to 44 years old (5260 of 28,870 [18.2%]), were nonwhite (3120 of 17,825 [17.5%]), were obese (5430 of 35,135 [15.5%]), and had polycystic ovarian syndrome (685 of 2385 [28.7%]). Patients with HS had 4.51 [95% confidence interval, 4.40-4.63] times the odds of having AV than did patients without HS, with the higher likelihood of having AV persisting across all subgroups of patients with HS. The association between HS and AV was generally stronger for patients who were male, and 65 years of age or older.

LIMITATIONS

Influence of disease severity in HS, or in acne, on the strength of the association could not be assessed.

CONCLUSION

Patients with HS may benefit from assessment of acne status and optimization of comanagement strategies.

摘要

背景

目前有关寻常痤疮（AV）与化脓性汗腺炎（HS）之间关联的证据有限，且患有 HS 的成年人中 AV 的患病负担尚不明确。

目的

确定患有 HS 的成年人中 AV 的患病率，并确定这种关联的强度。

方法

通过使用来自超过 5500 万患者的基于人群的样本的电子健康记录数据，进行横断面分析，以确定患有和不患有 HS 的患者中 AV 的成年人。

结果

与不患有 HS 的成年人（497360 例/16899470 例，2.9%）相比，患有 HS 的成年人中 AV 的患病率为 15.2%（7315 例/48085 例）（P<.001）。在患有 HS 的女性患者中（35790 例中的 5870 例，16.4%）、年龄为 18 至 44 岁的患者中（28870 例中的 5260 例，18.2%）、非白人患者中（17825 例中的 3120 例，17.5%）、肥胖患者中（35135 例中的 5430 例，15.5%）和多囊卵巢综合征患者中（2385 例中的 685 例，28.7%），AV 的患病率最高。与不患有 HS 的患者相比，患有 HS 的患者发生 AV 的可能性高 4.51 倍（95%置信区间，4.40-4.63），且这种发生 AV 的可能性在患有 HS 的所有亚组患者中均持续存在。对于男性和 65 岁或以上的患者，HS 与 AV 之间的关联通常更强。