美国化脓性汗腺炎患者 2 型糖尿病的患病率。

Prevalence of type 2 diabetes mellitus among patients with hidradenitis suppurativa in the United States.

机构信息

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

出版信息

J Am Acad Dermatol. 2018 Jul;79(1):71-76. doi: 10.1016/j.jaad.2018.01.014. Epub 2018 Jan 12.

DOI:10.1016/j.jaad.2018.01.014

PMID:29339240

Abstract

BACKGROUND

Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and type 2 diabetes mellitus (T2DM), and the existing data show conflicting results.

OBJECTIVE

To determine the prevalence of T2DM among patients with HS and identify at-risk demographic subgroups.

METHODS

Cross-sectional analysis identifying T2DM among patients with and without HS from a demographically heterogeneous population-based sample of more than 50 million patients in the United States.

RESULTS

The overall prevalence of T2DM among patients with HS was 24.8% (10,705 of 43,105) compared with 15.6% (1,993,320 of 12,527,570) among patients without HS. The prevalence was highest among patients with HS who were male (3045 of 10,785 [28.2%]), older (1945 of 3950 [49.2%]), nonwhite (4665 of 17,495 [26.7%]), obese (9065 of 30,855 [29.4%]), tobacco smokers (6880 of 25,005 [27.5%]), hypertensive (8595 of 19,610 [43.8%]), and hyperlipidemic (7965 of 17,190 [46.3%]). In univariable and multivariable analyses, patients with HS had 1.75 (95% confidence interval [CI], 1.71-1.79) and 1.58 (95% CI, 1.54-1.62) times the odds, respectively, of having T2DM. HS was associated with T2DM across all demographic subgroups. The association was stronger for younger patients (an OR of 1.67 and 95% CI of 1.60-1.72 for ages 18-44 years vs an OR of 1.50 and 95% CI of 1.41-1.61 for ages ≥65 years).

LIMITATIONS

We lacked information on HS disease severity.

CONCLUSION

Patients with HS with risk factors, signs, or symptoms of T2DM should be screened.

摘要

背景

很少有研究评估化脓性汗腺炎（HS）与 2 型糖尿病（T2DM）之间的关系，现有数据显示结果相互矛盾。

目的

确定患有 HS 的患者中 T2DM 的患病率，并确定有患病风险的人群亚组。

方法

通过对来自美国超过 5000 万患者的人口统计学异质性人群样本中的 HS 患者和非 HS 患者进行横断面分析，确定 T2DM 的患病率。

结果

与无 HS 的患者相比（15.6%，1993320/12527570），患有 HS 的患者中 T2DM 的总体患病率为 24.8%（10705/43105）。在 HS 患者中，男性（3045/10785[28.2%]）、年龄较大（1945/3950[49.2%]）、非白人（4665/17495[26.7%]）、肥胖（9065/30855[29.4%]）、吸烟者（6880/25005[27.5%]）、高血压（8595/19610[43.8%]）和高脂血症（7965/17190[46.3%]）患者的患病率最高。在单变量和多变量分析中，患有 HS 的患者分别具有 1.75（95%置信区间[CI]，1.71-1.79）和 1.58（95%CI，1.54-1.62）倍的 T2DM 发生几率。HS 与所有人群亚组的 T2DM 相关。在年轻患者中相关性更强（年龄 18-44 岁的 OR 为 1.67，95%CI 为 1.60-1.72，年龄≥65 岁的 OR 为 1.50，95%CI 为 1.41-1.61）。