Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Centre for Healthcare Modelling and Informatics, University of Portsmouth, Portsmouth, UK.
Resuscitation. 2019 Jan;134:147-156. doi: 10.1016/j.resuscitation.2018.09.026. Epub 2018 Oct 1.
To compare the ability of the National Early Warning Score (NEWS) and the National Early Warning Score 2 (NEWS2) to identify patients at risk of in-hospital mortality and other adverse outcomes.
We undertook a multi-centre retrospective observational study at five acute hospitals from two UK NHS Trusts. Data were obtained from completed adult admissions who were not fit enough to be discharged alive on the day of admission. Diagnostic coding and oxygen prescriptions were used to identify patients with type II respiratory failure (T2RF). The primary outcome was in-hospital mortality within 24 h of a vital signs observation. Secondary outcomes included unanticipated intensive care unit admission or cardiac arrest within 24 h of a vital signs observation. Discrimination was assessed using the c-statistic.
Among 251,266 adult admissions, 48,898 were identified to be at risk of T2RF by diagnostic coding. In this group, NEWS2 showed statistically significant lower discrimination (c-statistic, 95% CI) for identifying in-hospital mortality within 24 h (0.860, 0.857-0.864) than NEWS (0.881, 0.878-0.884). For 1394 admissions with documented T2RF, discrimination was similar for both systems: NEWS2 (0.841, 0.827-0.855), NEWS (0.862, 0.848-0.875). For all secondary endpoints, NEWS2 showed no improvements in discrimination.
NEWS2 modifications to NEWS do not improve discrimination of adverse outcomes in patients with documented T2RF and decrease discrimination in patients at risk of T2RF. Further evaluation of the relationship between SpO values, oxygen therapy and risk should be investigated further before wide-scale adoption of NEWS2.
比较国家早期预警评分(NEWS)和国家早期预警评分 2(NEWS2)识别住院患者死亡风险和其他不良结局的能力。
我们在来自英国两个国民保健署信托基金的五家急性医院进行了一项多中心回顾性观察研究。数据来自于入院当天因身体状况不佳而无法存活出院的成年患者。通过诊断编码和氧气处方来识别 II 型呼吸衰竭(T2RF)患者。主要结局是在生命体征观察后 24 小时内的院内死亡率。次要结局包括在生命体征观察后 24 小时内意外入住重症监护病房或心脏骤停。使用 C 统计量评估判别能力。
在 251266 名成年患者中,有 48898 人通过诊断编码被确定为 T2RF 风险患者。在该组中,NEWS2 用于识别 24 小时内院内死亡率的判别能力(C 统计量,95%CI)显著低于 NEWS(0.860,0.857-0.864)。对于有记录的 T2RF 的 1394 例入院患者,两种系统的判别能力相似:NEWS2(0.841,0.827-0.855),NEWS(0.862,0.848-0.875)。对于所有次要终点,NEWS2 在判别能力上没有改善。
NEWS2 对 NEWS 的修改并未提高有记录的 T2RF 患者不良结局的判别能力,反而降低了 T2RF 风险患者的判别能力。在广泛采用 NEWS2 之前,应进一步评估 SpO 值、氧气治疗与风险之间的关系。