Díaz Alejandro, Zócalo Yanina, Bia Daniel
Instituto de Investigación en Ciencias de la Salud, UNICEN - CONICET, 4 de Abril 618, 7000, Tandil, Buenos Aires Province, Argentina.
Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
Pediatr Cardiol. 2019 Feb;40(2):283-301. doi: 10.1007/s00246-018-2000-y. Epub 2018 Oct 4.
Despite the clinical utility of echocardiography to measure cardiac target organ injury (TOI) there are scarcities of data about the reference intervals (RIs) and percentiles of left ventricular (LV) mass (LVM) and derived indexes (LVMI and LVMI), relative wall thickness (LVRWT) and ejection fraction (LVEF) from population-based studies in children and adolescents. The aim of this study was to generate reference intervals RIs of LVM and derived indexes (LVMI and LVMI), LVRWT, and LVEF obtained in healthy children, adolescents, and young adults from a South-American population. Echocardiographic studies were obtained in 1096 healthy subjects (5-24 years). Age and sex-specific RIs of LVM, LVMI, LVMI, LVRWT, and LVEF were generated using parametric regression based on fractional polynomials. After covariate analysis (i.e., adjusting by age, body surface area) specific sex-specific RIs were evidenced as necessaries. Age and sex-specific 1st, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th, and 99th percentile and curves were reported and compared with previously reported RIs. RIs showed high concordance and complementarity with what was previously reported for the population of North-American children (0-18 years old). In conclusion, in children and adolescents the interpretation of the LVM, LVMIs, LVRWT, and LVEF RIs requires sex-related RIs. This study provides the largest Argentinean database concerning RIs and percentile curves of LVM, LVMIs, LVRWT, and LVEF as markers of cardiac TOI obtained in healthy children and adolescents. These data are valuable in that they provide RIs values with which data of populations of children, adolescents can be compared.
尽管超声心动图在测量心脏靶器官损伤（TOI）方面具有临床实用性，但关于儿童和青少年基于人群研究的左心室（LV）质量（LVM）及其衍生指标（LVMI和LVMI）、相对壁厚度（LVRWT）和射血分数（LVEF）的参考区间（RIs）和百分位数的数据却很匮乏。本研究的目的是生成南美人群中健康儿童、青少年和年轻成年人的LVM及其衍生指标（LVMI和LVMI）、LVRWT和LVEF的参考区间（RIs）。对1096名健康受试者（5 - 24岁）进行了超声心动图研究。使用基于分数多项式的参数回归生成了LVM、LVMI、LVMI、LVRWT和LVEF的年龄和性别特异性RIs。经过协变量分析（即按年龄、体表面积进行调整）后，证实特定性别特异性RIs是必要的。报告了年龄和性别特异性的第1、2.5、5、10、25、50、75、90、95、97.5和99百分位数及曲线，并与先前报道的RIs进行了比较。RIs与先前报道的北美儿童（0 - 18岁）人群的数据显示出高度的一致性和互补性。总之，在儿童和青少年中，LVM、LVMIs、LVRWT和LVEF RIs的解释需要与性别相关的RIs。本研究提供了关于LVM、LVMIs、LVRWT和LVEF作为心脏TOI标志物的RIs和百分位数曲线的最大阿根廷数据库，这些数据来自健康儿童和青少年。这些数据很有价值，因为它们提供了可用于比较儿童、青少年人群数据的RIs值。
