Department of Biotechnology, University of Kashmir, Hazratbal, Srinagar, 190006, India.
Apoptosis. 2019 Feb;24(1-2):3-20. doi: 10.1007/s10495-018-1490-7.
TGF-β activated kinase 1, a MAPK kinase kinase family serine threonine kinase has been implicated in regulating diverse range of cellular processes that include embryonic development, differentiation, autophagy, apoptosis and cell survival. TAK1 along with its binding partners TAB1, TAB2 and TAB3 displays a complex pattern of regulation that includes serious crosstalk with major signaling pathways including the C-Jun N-terminal kinase (JNK), p38 MAPK, and I-kappa B kinase complex (IKK) involved in establishing cellular commitments for death and survival. This review also highlights how TAK1 orchestrates regulation of energy homeostasis via AMPK and its emerging role in influencing mTORC1 pathway to regulate death or survival in tandem.
转化生长因子-β激活激酶 1（TGF-β activated kinase 1，TAK1），一种丝氨酸苏氨酸激酶的丝裂原活化蛋白激酶激酶激酶家族成员，已被牵涉到调节包括胚胎发育、分化、自噬、细胞凋亡和细胞存活等多种细胞过程中。TAK1 及其结合伙伴 TAB1、TAB2 和 TAB3 显示出复杂的调节模式，包括与主要信号通路（包括参与建立死亡和存活的细胞承诺的 c-Jun N 末端激酶（JNK）、p38MAPK 和 IκB 激酶复合物（IKK））的严重串扰。这篇综述还强调了 TAK1 如何通过 AMPK 来协调能量稳态的调节，以及它在影响 mTORC1 通路以协调死亡或存活方面的新兴作用。
