Lauzeille Delphine, Guerlais Marylène, Sallenave-Namont Claire, Etcheverrigaray François, Broccato Luciano, Poisblaud Quentin, Jolliet Pascale, Victorri-Vigneau Caroline
Pharmacology department, Centre d'Evaluation et d'Information sur la Pharmacodépendance - Addictovigilance (CEIP-A), Institut de Biologie, 9 quai Moncousu, 44093 Nantes cedex 01, France.
Pharmacy Faculty, UFR Sciences Pharmaceutiques et Biologiques, 9 rue Bias BP 61112 44035, Nantes cedex 1, France.
Fundam Clin Pharmacol. 2019 Apr;33(2):216-222. doi: 10.1111/fcp.12420. Epub 2018 Nov 21.
The principal outcome was to identify which hypnotics substances, medicated (benzodiazepines, antihistamine, antidepressant…) or not medicated (herbal medicine, homeopathy, melatonin…), were consumed by community pharmacy patients who reported taking something for sleep disorder, and which factors can influence the consumption of medicated substance rather than nonmedicated substance. Data were collected via a network of 73 partner pharmacies around Nantes, France. Patients who reported taking a substance to sleep completed a questionnaire that collected data relative to the different substances consumed by that person for sleep, and the desired effect. Substances were classified in Hypnotic Drug Substances and nonmedicated hypnotic substances. A logistical regression was done in order to highlight the factors associated with the consumption of Hypnotic Drug Substance rather than nonmedicated hypnotic substances. Six hundred and forty-seven patients were included, with an average age of 58 years and 74% female. The principal strategy employed to combat sleep disorder was the consumption of Hypnotic Drug Substance (54%), followed by herbal medicine (32%) and homeopathy (19%). The factors positively associated with the consumption of a Hypnotic Drug Substance are age, living alone, being out of work, or in the process of looking for a job and being a parent. In our survey, the use of Hypnotic Drug Substance to help patients with sleep is far from systematic. On the other hand, among patients who consume HDS, misuse is still significant, particularly in terms of the duration of consumption.
主要结果是确定哪些催眠物质，无论是药用的（苯二氮卓类、抗组胺药、抗抑郁药等）还是非药用的（草药、顺势疗法、褪黑素等），被报告有睡眠障碍的社区药房患者所使用，以及哪些因素会影响药用物质而非非药用物质的使用。数据通过法国南特周围73家合作药房的网络收集。报告服用某种物质助眠的患者填写了一份问卷，收集该人用于睡眠的不同物质及预期效果的数据。物质被分为催眠药物物质和非药用催眠物质。进行了逻辑回归分析，以突出与使用催眠药物物质而非非药用催眠物质相关的因素。纳入了647名患者，平均年龄58岁，女性占74%。对抗睡眠障碍的主要策略是使用催眠药物物质（54%），其次是草药（32%）和顺势疗法（19%）。与使用催眠药物物质呈正相关的因素有年龄、独居、失业、正在找工作以及为人父母。在我们的调查中，使用催眠药物物质帮助患者睡眠的情况远非普遍。另一方面，在使用催眠药物物质的患者中，滥用情况仍然严重，尤其是在用药时长方面。
