Zheng Chenfei, Xu Jinglin, Chen Chaosheng, Lin Fan, Shao Rongrong, Lin Ze, Liu Yi, Zhou Ying
Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Department of Nephrology, Taizhou First Person's Hospital, Taizhou, 318020, China.
Int Urol Nephrol. 2019 Jan;51(1):163-174. doi: 10.1007/s11255-018-2018-3. Epub 2018 Nov 22.
Sleep disorders are very common among dialysis patients, leading patients to frequently take sedative-hypnotic medications; however, the effects of sleep disorders and the use of such drugs on health-related quality of life (HRQOL) have rarely been investigated.
The Pittsburgh Sleep Quality Index and Short Form-12 were used to assess sleep quality and patient health situations, respectively. Logistic regression was employed to identify factors associated with deterioration of the mental component summary (MCS) score and the physical component summary (PCS) score.
A total of 461 patients undergoing dialysis were recruited. The prevalence of sleep disorders was 67.0%. Among the study population, 30.4% of patients took sedative-hypnotic medications to improve their sleep quality. Both the PCS (81.25 vs. 71.88, p < 0.001) and MCS scores (78.63 vs. 74.63, p < 0.001), which indicate HRQOL, were decreased among patients with sleep disorders compared with good sleepers. However, neither the PCS nor MCS scores showed any significant difference between patients with sleep disorders who used sedative-hypnotic medications and those who did not.
Sleep disorders were closely associated with deterioration of both mental HRQOL and physical HRQOL. Sedative-hypnotic medication use did not affect HRQOL among patients with sleep disorders undergoing dialysis.
睡眠障碍在透析患者中非常常见，导致患者频繁服用镇静催眠药物；然而，睡眠障碍及此类药物的使用对健康相关生活质量（HRQOL）的影响鲜有研究。
分别采用匹兹堡睡眠质量指数和简明健康调查量表12项来评估睡眠质量和患者健康状况。采用逻辑回归分析确定与精神健康综合评分（MCS）和生理健康综合评分（PCS）恶化相关的因素。
共纳入461例接受透析的患者。睡眠障碍的患病率为67.0%。在研究人群中，30.4%的患者服用镇静催眠药物以改善睡眠质量。与睡眠良好者相比，睡眠障碍患者的HRQOL指标PCS评分（81.25对71.88，p<0.001）和MCS评分（78.63对74.63，p<0.001）均降低。然而，使用镇静催眠药物的睡眠障碍患者与未使用的患者之间，PCS评分和MCS评分均无显著差异。
睡眠障碍与精神HRQOL和生理HRQOL的恶化密切相关。使用镇静催眠药物对接受透析的睡眠障碍患者的HRQOL没有影响。
