一种 IFNL4 基因缺失突变与经性传播的 HIV-1 感染的保护作用相关。

A Knockout IFNL4 Variant Is Associated With Protection From Sexually Transmitted HIV-1 Infection.

机构信息

Immunogenetics Unit, Department of Experimental Biology, Universidad de Jaén, Jaen.

Research Group of the Bacteriology and Clinical Laboratory Program, Faculty of Health Sciences, Universidad de Boyacá, Tunja, Colombia.

出版信息

J Infect Dis. 2019 Feb 15;219(5):772-776. doi: 10.1093/infdis/jiy584.

DOI:10.1093/infdis/jiy584

PMID:30289470

Abstract

An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection. The role of this polymorphism in the susceptibility to human immunodeficiency virus type 1 (HIV-1) infection is controversial. This study aimed to assess the association of this knockout IFNL4 variant and sexually transmitted HIV-1 infection. A total of 228 HIV-1-positive individuals and 136 HIV-exposed seronegative individuals were investigated for their association with IFNL4 rs368234815 genotypes. The IFNL4 ΔG functional allele is associated with increased susceptibility to HIV-1 infection through the sexual route (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.2-3.6; P = .004). A meta-analysis including a population of injection drug users suggests a codominant mode of inheritance of this risk factor (OR, 2.0; 95% CI, 1.3-3.2; P = .001).

摘要

干扰素 λ4 基因 (IFNL4) 缺失等位基因 (rs368234815; TT) 与丙型肝炎病毒感染的自发性和 IFN-α 依赖性治愈有关。该多态性在人类免疫缺陷病毒 1 型 (HIV-1) 感染易感性中的作用存在争议。本研究旨在评估这种缺失 IFNL4 变体与性传播 HIV-1 感染的关联。共调查了 228 名 HIV-1 阳性个体和 136 名 HIV 暴露阴性个体，以评估其与 IFNL4 rs368234815 基因型的关联。IFNL4 ΔG 功能性等位基因通过性途径与 HIV-1 感染的易感性增加相关（比值比 [OR]，2.1；95%置信区间 [CI]，1.2-3.6；P =.004）。一项包括注射吸毒者人群的荟萃分析表明，这种风险因素具有共显性遗传模式（OR，2.0；95% CI，1.3-3.2；P =.001）。