Hox 在壁龛中控制毛发生长。

Hox in the Niche Controls Hairy-geneity.

机构信息

Departments of Dermatology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA.

出版信息

Cell Stem Cell. 2018 Oct 4;23(4):457-458. doi: 10.1016/j.stem.2018.09.012.

DOI:10.1016/j.stem.2018.09.012

PMID:30290171

Abstract

Patterns of mammalian hair growth vary in different regions of the body, but the mechanisms controlling this heterogeneity are unclear. In this issue of Cell Stem Cell, Yu et al. (2018) show that Hoxc gene expression in hair follicle mesenchyme varies along the anterior-posterior body axis and contributes to regional differences in hair growth.

摘要

哺乳动物身体不同区域的毛发生长模式存在差异，但控制这种异质性的机制尚不清楚。在本期《Cell Stem Cell》杂志上，Yu 等人（2018）表明，毛囊间充质细胞中的 Hoxc 基因表达沿身体前后轴变化，并有助于毛发生长的区域差异。