Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.
Genome Unit, Faculty of Medicine, Cairo University, Egypt.
Arch Oral Biol. 2018 Dec;96:189-194. doi: 10.1016/j.archoralbio.2018.09.015. Epub 2018 Sep 26.
This study aimed to determine the association of rs2430561 and rs4073 polymorphisms in the Interferon gamma (IFN-ɤ) and Interleukin 8 (IL-8) genes, respectively, with hepatitis C virus-related oral lichen planus and disease severity.
This is a case-control study. 60 subjects were equally divided into patients with and without oral lichen planus. They were further subdivided into hepatitis C virus seropositive and seronegative patients. All patients were genotyped for IFN-γ rs2430561 thymine to adenine (T > A) and IL-8 rs4073 adenine to thymine (A > T) polymorphisms. All patients with oral lichen planus had their lesions measured and documented using the Escudier scoring system.
Disease activity was significantly higher in the "oral lichen planus/hepatitis C virus-positive" patients than in the "oral lichen planus/hepatitis C virus-negative" patients (P = 0.003). IFN-γ rs2430561 T > A and IL-8 rs4073 A > T genotypes and allele frequencies were not associated with the oral lichen planus group or the normal group. Stratification of the two groups into HCV and non-HCV-infected patients or into erosive and non-erosive types revealed no significant associations. The "A-allele-containing" genotypes of IL-8 rs4073 A > T were significantly more prevalent in the patients with oral lichen planus than in those without.
Hepatitis C virus infection is associated with the development of erosive oral lichen planus. The A-allele of IL-8 rs4073 A > T may have a role in the development and progression of oral lichen planus.
本研究旨在确定干扰素γ（IFN-ɤ）和白细胞介素 8（IL-8）基因中的 rs2430561 和 rs4073 多态性与丙型肝炎病毒相关口腔扁平苔藓及疾病严重程度的关系。
这是一项病例对照研究。60 名受试者被平均分为口腔扁平苔藓患者和无口腔扁平苔藓患者。他们进一步分为丙型肝炎病毒血清阳性和血清阴性患者。所有患者均进行 IFN-γ rs2430561 胸腺嘧啶到腺嘌呤（T> A）和 IL-8 rs4073 腺嘌呤到胸腺嘧啶（A> T）多态性的基因分型。所有口腔扁平苔藓患者的病变均采用 Escudier 评分系统进行测量和记录。
“口腔扁平苔藓/丙型肝炎病毒阳性”患者的疾病活动度明显高于“口腔扁平苔藓/丙型肝炎病毒阴性”患者（P=0.003）。IFN-γ rs2430561 T> A 和 IL-8 rs4073 A> T 基因型和等位基因频率与口腔扁平苔藓组或正常组无关。将两组分为丙型肝炎病毒和非丙型肝炎病毒感染患者或糜烂性和非糜烂性类型，未发现显著相关性。IL-8 rs4073 A> T 的“含 A 等位基因”基因型在口腔扁平苔藓患者中明显更为常见。
丙型肝炎病毒感染与糜烂性口腔扁平苔藓的发生有关。IL-8 rs4073 A> T 的 A 等位基因可能在口腔扁平苔藓的发生和发展中起作用。
