Li An-An, Cao Zhi-Yuan, Liu Jia-Ming, Huang Shan-Hu, Liu Zhi-Li
Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, P.R. China.
Medicine (Baltimore). 2018 Oct;97(40):e12694. doi: 10.1097/MD.0000000000012694.
This retrospective analysis aim to evaluate the potential risk factors for bone metastases (BM) in patients who were diagnosed with colorectal cancer (CRC).A total of 2790 patients diagnosed with CRC between January 2006 and December 2016 were collected in this study. All patients were divided into 2 groups, BM and no BM. The associations between biomarkers (including age, gender, histopathological types, alkaline phosphatase (ALP), carcinoembryonic antigen (CEA), cancer antigen 125, and so on), and BM in patients with CRC were analyzed. All the analyses were conducted by SPSS software (version 22.0, SPSS, Chicago, IL).Of all patients, 74 (2.7%) were identified with BM. The level of serum ALP, CEA, and cancer antigen 125 in patients with BM were obviously higher than those without BM (P < .001, P = .005, and P < .001). And the cut-off values of ALP, CEA, and cancer antigen 125 were 85.5 U/L, 6.9 mmol/L, and 16.8 mmol/L, respectively.ALP, CEA, and cancer antigen 125 were identified as the independent risk factors for BM in patients with CRC.
本回顾性分析旨在评估被诊断为结直肠癌（CRC）的患者发生骨转移（BM）的潜在危险因素。本研究收集了2006年1月至2016年12月期间共2790例被诊断为CRC的患者。所有患者被分为两组，即发生骨转移组和未发生骨转移组。分析了生物标志物（包括年龄、性别、组织病理学类型、碱性磷酸酶（ALP）、癌胚抗原（CEA）、癌抗原125等）与CRC患者骨转移之间的关联。所有分析均使用SPSS软件（版本22.0，SPSS，伊利诺伊州芝加哥）进行。在所有患者中，74例（2.7%）被确定发生了骨转移。发生骨转移患者的血清ALP、CEA和癌抗原125水平明显高于未发生骨转移的患者（P<0.001，P=0.005，P<0.001）。ALP、CEA和癌抗原125的截断值分别为85.5 U/L、6.9 mmol/L和16.8 mmol/L。ALP、CEA和癌抗原125被确定为CRC患者发生骨转移的独立危险因素。
