Department of Endocrinology, Weihai Hospital Affiliated to Medical College of Qingdao University, No 51 Guangming road, Huancui District, Weihai, 264200, China.
Department of Endocrinology and Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao, China.
Lipids Health Dis. 2018 Oct 5;17(1):229. doi: 10.1186/s12944-018-0878-2.
The association of serum high-density lipoprotein cholesterol (HDL-C) with microalbuminuria in type 2 diabetes mellitus (T2DM) remains controversial. Therefore, a cross-sectional study was conducted on patients with T2DM to investigate the relationship of HDL-C with microalbuminuria.
A total of 524 participants with T2DM were recruited in this cross-sectional study. The patients were divided into four groups according to serum HDL-C quartile. A nonparametric test was employed to assess the relationships across quartiles with clinical parameters and demographics. Multivariate logistic regression analysis was further performed.
Of the 524 patients, 138 (26.3%) were found to have microalbuminuria by urinary albumin excretion rate determination. Serum HDL-C levels in microalbuminuria group were significantly lower than those in non-microalbuminuria group (1.04 (0.90-1.21) vs. 1.10 (0.94-1.31) mmol/L, P = 0.002). The nonparametric test for trend showed that the prevalence of microalbuminuria was significantly reduced for subjects of the fourth quartile of HDL-C compared to the first to third quartile (13.5% vs. 33.1%, 28.6%, 29.4%, P = 0.001). Multivariate logistic regression showed that subjects within the highest quartile of HDL-C had lower odds of microalbuminuria than those within the lowest quartile of HDL-C (OR = 0.17, 95% CI 0.15-0.52, P = 0.004).
Higher levels of serum HDL-C were associated with decreased rates of microalbuminuria in T2DM patients.
血清高密度脂蛋白胆固醇（HDL-C）与 2 型糖尿病（T2DM）患者微量白蛋白尿的关系仍存在争议。因此，本研究对 T2DM 患者进行了横断面研究，以探讨 HDL-C 与微量白蛋白尿的关系。
本横断面研究共纳入 524 例 T2DM 患者。根据血清 HDL-C 四分位距将患者分为 4 组，采用非参数检验评估各四分位距与临床参数和人口统计学特征的关系。进一步进行多变量 logistic 回归分析。
524 例患者中，根据尿白蛋白排泄率确定有 138 例（26.3%）发生微量白蛋白尿。微量白蛋白尿组血清 HDL-C 水平明显低于非微量白蛋白尿组（1.04（0.90-1.21）比 1.10（0.94-1.31）mmol/L，P=0.002）。趋势检验的非参数检验显示，与 HDL-C 四分位距 1-3 分位相比，HDL-C 四分位距 4 分位的患者微量白蛋白尿患病率明显降低（13.5%比 33.1%、28.6%、29.4%，P=0.001）。多变量 logistic 回归分析显示，HDL-C 四分位距最高组患者微量白蛋白尿的发生风险低于 HDL-C 四分位距最低组（OR=0.17，95%CI 0.15-0.52，P=0.004）。
T2DM 患者血清 HDL-C 水平较高与微量白蛋白尿发生率降低相关。
