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韩国 2 型糖尿病患者微量白蛋白尿的风险因素:基于 2019-2020 年韩国国家健康和营养检查调查数据的横断面研究。

Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea: A Cross-Sectional Study Based on 2019-2020 Korea National Health and Nutrition Examination Survey Data.

机构信息

Good Aein Medical Care Hospital, Busan 47889, Republic of Korea.

Department of Nursing, Saekyung University, Yeongwol-gun 26239, Gangwon-do, Republic of Korea.

出版信息

Int J Environ Res Public Health. 2023 Feb 25;20(5):4169. doi: 10.3390/ijerph20054169.

Abstract

Diabetes mellitus is a chronic disease with high economic and social burdens. This study aimed to determine the risk factors of microalbuminuria among patients with type 2 diabetes mellitus. Microalbuminuria is predictive of early-stage renal complications and subsequent progression to renal dysfunction. We collected data on type 2 diabetes patients who participated in the 2019-2020 Korea National Health and Nutrition Examination Survey. The risk factors for microalbuminuria among patients with type 2 diabetes were analyzed using logistic regression. As a result, the odds ratios were 1.036 (95% confidence interval (CI) = 1.019-1.053, < 0.001) for systolic blood pressure, 0.966 (95% CI = 0.941-0.989, = 0.007) for high-density lipoprotein cholesterol level, 1.008 (95% CI = 1.002-1.014, 0.015) for fasting blood sugar level, and 0.855 (95% CI = 0.729-0.998, = 0.043) for hemoglobin level. A significant strength of this study is the identification of low hemoglobin level (i.e., anemia) as a risk factor for microalbuminuria in patients with type 2 diabetes. This finding implies that the early detection and management of microalbuminuria can prevent the development of diabetic nephropathy.

摘要

糖尿病是一种具有高经济和社会负担的慢性疾病。本研究旨在确定 2 型糖尿病患者发生微量白蛋白尿的危险因素。微量白蛋白尿可预测早期肾脏并发症,并随后进展为肾功能不全。我们收集了参加 2019-2020 年韩国国家健康和营养检查调查的 2 型糖尿病患者的数据。使用逻辑回归分析 2 型糖尿病患者微量白蛋白尿的危险因素。结果显示,收缩压的比值比为 1.036(95%置信区间[CI] = 1.019-1.053,<0.001),高密度脂蛋白胆固醇水平的比值比为 0.966(95%CI = 0.941-0.989,= 0.007),空腹血糖水平的比值比为 1.008(95%CI = 1.002-1.014, 0.015),血红蛋白水平的比值比为 0.855(95%CI = 0.729-0.998,= 0.043)。本研究的一个显著优势是确定低血红蛋白水平(即贫血)是 2 型糖尿病患者微量白蛋白尿的危险因素。这一发现意味着早期检测和管理微量白蛋白尿可以预防糖尿病肾病的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddf0/10002237/36ff810b502c/ijerph-20-04169-g001.jpg

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